iPTMnet Report for O14964 (HGS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14964 / HGS_HUMAN
Protein Name Hepatocyte growth factor-regulated tyrosine kinase substrate
Gene Name Name: HGS
Synonyms:HRS;
Organism Homo sapiens (Human)

PRO ID PR:O14964
DAG View
PRO Name hepatocyte growth factor-regulated tyrosine kinase substrate (human)
Definition A hepatocyte growth factor-regulated tyrosine kinase substrate that is encoded in the genome of human.
Short Label hHGS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14964 (HGS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K136 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K207 Acetylation PhosphoSitePlus   UniProt 19608861
K207 Ubiquitination PhosphoSitePlus
Y216 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107
K222 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
Y289 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S297 O-Glycosylation GlyGen 35008409, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 29351928, 35132862, 30620550, 29485866, 32119511, 35254053, 22661428
S299 O-Glycosylation GlyGen 35008409, 33214551, 32938750, ...35138101, 30379171, 34725712, 28510447, 34019948, 35254053, 35132862, 30620550, 29485866, 32119511, 29351928, 22661428
S300 O-Glycosylation GlyGen 35008409, 33214551, 32938750, ...35138101, 30379171, 34725712, 28510447, 34019948, 35254053, 35132862, 30620550, 29485866, 32119511, 29351928, 22661428
S305 O-Glycosylation GlyGen 30379171
S305 Phosphorylation PhosphoSitePlus
S306 O-Glycosylation GlyGen 30379171
S306 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation phospho.ELM   PhosphoSitePlus 16212419
S309 O-Glycosylation GlyGen 30379171
S309 Phosphorylation PhosphoSitePlus
S310 O-Glycosylation GlyGen 35008409, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 29351928, 35132862, 30620550, 29485866, 32119511, 35254053, 22661428
S310 Phosphorylation phospho.ELM 18669648
S315 O-Glycosylation GlyGen 35008409, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 29351928, 35132862, 30620550, 29485866, 32119511, 35254053, 22661428
Y329 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12953068, 17101784
Y329 Phosphorylation P00533 (EGFR) phospho.ELM   Signor 12953068
Y334 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17101784, 12953068, 11687594
Y334 Phosphorylation P00533 (EGFR) neXtProt   Signor 12953068
K337 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
Y467 Phosphorylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
K494 Acetylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
Y524 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
R557 Methylation PhosphoSitePlus
Y567 Phosphorylation PhosphoSitePlus
T625 Phosphorylation IEDB 32387766
Site PTM Type PTM Enzyme Score Source PMID
Y132 Phosphorylation HPRD 18083107, 19901323
S198 Phosphorylation HPRD 20068231
Y216 Phosphorylation HPRD 15592455, 16497976
S240 Phosphorylation HPRD 19413330
Y308 Phosphorylation HPRD 17016520, 16212419
S310 Phosphorylation HPRD 18669648, 20068231
Y329 Phosphorylation HPRD 17016520, 12953068
Y329 Phosphorylation P00533 (EGFR) HPRD 17016520, 12953068
Y334 Phosphorylation HPRD 17016520, 19901323, 11687594
S345 Phosphorylation HPRD 20058876
Y567 Phosphorylation HPRD 20068231
S594 Phosphorylation HPRD 20068231
T625 Phosphorylation HPRD 20068231