iPTMnet Report for O14950 (MYL12B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14950 / ML12B_HUMAN
Protein Name Myosin regulatory light chain 12B
Gene Name Name: MYL12B
Synonyms:MRLC2,MYLC2B;
Organism Homo sapiens (Human)

PRO ID PR:O14950
DAG View
PRO Name myosin regulatory light chain 12B (human)
Definition A myosin regulatory light chain 12B that is encoded in the genome of human.
Short Label hMYL12B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14950 (MYL12B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation P17252 (PRKCA) neXtProt   PhosphoSitePlus 18835557
T11 Phosphorylation PhosphoSitePlus
T19 Phosphorylation Q12852 (MAP3K12) , Q13418 (ILK) , O43293 (DAPK3) , P17252 (PRKCA) , Q13464 (ROCK1) , Q15746 (MYLK) HPRD   neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 11942626, 12185584, 17287340, ...18212344, 15946647, 12429016, 10356987, 1178183, 26334100, 11278951, 18835557, 11384979, 15226371, 11781833
S20 Phosphorylation Q13464 (ROCK1) , Q13418 (ILK) , Q15746 (MYLK) , Q96GD4 (AURKB) , P17252 (PRKCA) , Q12852 (MAP3K12) , O43293 (DAPK3) , P53355 (DAPK1) HPRD   IEDB   neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 10356987, 15226371, 16472257, ...11384979, 18452278, 18212344, 18835557, 12429016, 12571246, 15676024, 1178183, 26334100, 17056602, 12185584, 10233893, 11278951, 32387766, 18648664, 11942626, 17287340, 15946647, 11781833
S29 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
C109 Methylation IEDB 31844290
T128 Phosphorylation PhosphoSitePlus
R133 Methylation PhosphoSitePlus
T135 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 6593002
Y143 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K151 Sumoylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048496 (hMYL12B/Phos:1) pT19 PRO
PR:000048497 (hMYL12B/Phos:2) pT19,pS20 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T19 A19 Biomuta DOID:3571 / liver cancer [ cosmic ]
S60 Y60 Biomuta DOID:363 / uterine cancer [ icgc ]
C109 W109 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]