Protein Information

Cytoscape View


UniProt AC / UniProt ID O14936 / CSKP_HUMAN
Protein Name Peripheral plasma membrane protein CASK
Gene Name Name: CASK
Synonyms:LIN2;
Organism Homo sapiens (Human)

PRO ID PR:O14936
DAG View
PRO Name peripheral plasma membrane protein CASK (human)
Definition A peripheral plasma membrane protein CASK that is encoded in the genome of human.
Short Label hCASK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14936 (CASK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K41 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S51 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 18054859, 23186163
S55 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S151 Phosphorylation O14936 (CASK) PhosphoSitePlus   UniProt 18423203
S155 Phosphorylation O14936 (CASK) PhosphoSitePlus   UniProt 18423203
T182 Phosphorylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus   UniProt 24275569
S314 Phosphorylation PhosphoSitePlus
Y387 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
S395 Phosphorylation neXtProt   PhosphoSitePlus 18054859
K410 Ubiquitination PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S562 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 20067577
S570 Phosphorylation PhosphoSitePlus
Y571 Phosphorylation PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K703 Methylation PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
K704 Methylation PhosphoSitePlus
Y708 Phosphorylation PhosphoSitePlus
Y712 Phosphorylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K738 Methylation PhosphoSitePlus
T741 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 20067577
K756 Ubiquitination PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
Y769 Phosphorylation PhosphoSitePlus
T775 Phosphorylation PhosphoSitePlus
Y788 Phosphorylation PhosphoSitePlus
Y789 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T49 Phosphorylation HPRD 18691976
S51 Phosphorylation HPRD 20068231
S394 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S319 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus


O14936 (CASK) as PTM Enzyme



Substrate Site Score Source PMID
O14936 (CASK) S151 PhosphoSitePlus   UniProt 18423203
O14936 (CASK) S155 PhosphoSitePlus   UniProt 18423203


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K41 T41 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K41 R41 Biomuta DOID:363 / uterine cancer [ tcga ]
S155 * Biomuta DOID:3571 / liver cancer [ icgc ]
S600 Y600 Biomuta DOID:363 / uterine cancer [ tcga ]
K703 N703 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y708 C708 Biomuta DOID:363 / uterine cancer [ tcga ]
T741 A741 Biomuta DOID:363 / uterine cancer [ tcga ]
Y769 C769 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y789 * Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
K825 R825 Biomuta DOID:0070003 / blastoma [ cosmic ]