iPTMnet Report for O14936 (CASK)
Protein Information
| UniProt AC / UniProt ID | O14936 / CSKP_HUMAN |
| Protein Name | Peripheral plasma membrane protein CASK |
| Gene Name | Name: CASK Synonyms:LIN2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O14936 |
| PRO Name | peripheral plasma membrane protein CASK (human) |
| Definition | A peripheral plasma membrane protein CASK that is encoded in the genome of human. |
| Short Label | hCASK |
| Category | organism-gene |
DAG ViewO14936 (CASK) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K41 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K47 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S50 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S51 | Phosphorylation | score4 | neXtProt PhosphoSitePlus UniProt | 18054859, 23186163 | ||
| S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K60 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S151 | Phosphorylation | O14936 (CASK) | score3 | PhosphoSitePlus UniProt | 18423203 | |
| S155 | Phosphorylation | O14936 (CASK) | score3 | PhosphoSitePlus UniProt | 18423203 | |
| T182 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K192 | Phosphorylation | score1 | UniProt | 24275569 | ||
| Y282 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S313 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S314 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y321 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y387 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K393 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S395 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 18054859 | ||
| K410 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T460 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S465 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S562 | Phosphorylation | P17612 (PRKACA) | score3 | neXtProt PhosphoSitePlus | 20067577 | |
| S570 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y571 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| T573 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S577 | Phosphorylation | score1 | UniProt | 24275569 | ||
| S582 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S600 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y616 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C633 | Methylation | score1 | IEDB | 31844290 | ||
| S650 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K665 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K689 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K691 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K703 | Methylation | score1 | PhosphoSitePlus | |||
| K703 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K704 | Methylation | score1 | PhosphoSitePlus | |||
| Y708 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y712 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K715 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K738 | Methylation | score1 | PhosphoSitePlus | |||
| T741 | Phosphorylation | P17612 (PRKACA) | score3 | neXtProt PhosphoSitePlus | 20067577 | |
| K756 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T761 | O-Glycosylation | score1 | GlyGen | 29237092 | ||
| K762 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y769 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T775 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y788 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y789 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S792 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K825 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K843 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T49 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S51 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S394 | Phosphorylation | score0 | HPRD | 20068231 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S319 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S569 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S570 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S571 | Phosphorylation | score1 | PhosphoSitePlus |
O14936 (CASK) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O14936 (CASK) | S151 | score3 | PhosphoSitePlus UniProt | 18423203 | |
| O14936 (CASK) | S155 | score3 | PhosphoSitePlus UniProt | 18423203 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K41 | T41 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S50 | * | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| T182 | A182 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K192 | R192 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S394 | Y394 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| S570 | L570 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| Y571 | C571 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
| T573 | N573 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S600 | P600 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K703 | N703 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| K715 | R715 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T741 | A741 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y769 | C769 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K825 | R825 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] |
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