iPTMnet Report for O14924 (RGS12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14924 / RGS12_HUMAN
Protein Name Regulator of G-protein signaling 12
Gene Name Name: RGS12
Organism Homo sapiens (Human)

PRO ID PR:O14924
DAG View
PRO Name regulator of G-protein signaling 12 (human)
Definition A regulator of G-protein signaling 12 that is encoded in the genome of human.
Short Label hRGS12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14924 (RGS12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
T492 Phosphorylation PhosphoSitePlus
R524 Methylation PhosphoSitePlus   UniProt 24129315
R633 Methylation PhosphoSitePlus
R643 Methylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
T676 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
T866 Phosphorylation PhosphoSitePlus
S874 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S876 Phosphorylation PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
S889 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S909 Phosphorylation PhosphoSitePlus
S934 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S937 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
S940 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S947 Phosphorylation PhosphoSitePlus
K962 Acetylation PhosphoSitePlus
K979 Acetylation PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
K1115 Ubiquitination PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
S1148 Phosphorylation PhosphoSitePlus
K1211 Ubiquitination PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus
S1304 Phosphorylation PhosphoSitePlus
S1321 Phosphorylation PhosphoSitePlus
T1331 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S874 Phosphorylation HPRD 17287340
S889 Phosphorylation HPRD 17287340
S934 Phosphorylation HPRD 17525332, 18077418
S940 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S226 Phosphorylation HPRD 17287340
S241 Phosphorylation HPRD 17287340
S286 Phosphorylation HPRD 17525332, 18077418
S292 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S874 Phosphorylation HPRD 17287340
S889 Phosphorylation HPRD 17287340
S934 Phosphorylation HPRD 17525332, 18077418
S940 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 L16 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S286 L286 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc ]
S435 G435 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T492 A492 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R633 W633 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R633 Q633 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S649 L649 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S661 F661 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T676 M676 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S711 G711 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T866 M866 Biomuta DOID:1319 / brain cancer [ icgc ]
S876 F876 Biomuta DOID:4159 / skin cancer [ cosmic ]
S909 F909 Biomuta DOID:4159 / skin cancer [ cosmic ]
S934 L934 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K979 E979 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1148 Y1148 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1211 T1211 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1331 M1331 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]