iPTMnet Report for O14920 (IKBKB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14920 / IKKB_HUMAN
Protein Name Inhibitor of nuclear factor kappa-B kinase subunit beta
Gene Name Name: IKBKB
Synonyms:IKKB;
Organism Homo sapiens (Human)

PRO ID PR:O14920
DAG View
PRO Name inhibitor of nuclear factor kappa-B kinase subunit beta (human)
Definition An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human.
Short Label hIKBKB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14920 (IKBKB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus   UniProt 16267042
Y169 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PR:000035736 (hMAP3K7/Phos:1) , P17252 (PRKCA) , Q02156 (PRKCE) , Q99558 (MAP3K14) , Q05513 (PRKCZ) , P54646 (PRKAA2) , O43318 (MAP3K7) , Q9UHD2 (TBK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11460167, 10195894, 23123196, ...32019925, 24611898, 16267042, 30108917, 24755559, 22590573, 21673972, 23671281, 10022904, 10779355, 17079871, 25195736, 10783893
C179 S-Nitrosylation dbSNO 15184672, 22178444, 15688001
T180 Acetylation PhosphoSitePlus
T180 Phosphorylation PhosphoSitePlus
S181 Phosphorylation Q9UHD2 (TBK1) , P17252 (PRKCA) , O00141 (SGK1) , O15530 (PDPK1) , Q99558 (MAP3K14) , P54646 (PRKAA2) , PR:000035736 (hMAP3K7/Phos:1) , Q9Y6K9 (IKBKG) , O14920 (IKBKB) , Q05513 (PRKCZ) , O43318 (MAP3K7) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11460167, 15695387, 32019925, ...10195894, 16267042, 30108917, 24611898, 10022904, 22590573, 24911653, 17079871, 24755559, 25195736, 21673972, 20167598, 16207722, 18037881, 26838742, 18240344, 10783893
Y188 Phosphorylation P07948 (LYN) , P12931 (SRC) neXtProt   PhosphoSitePlus   Signor 12707358, 12645577, 26353931
Y199 Phosphorylation P12931 (SRC) , P07948 (LYN) neXtProt   PhosphoSitePlus   Signor 12645577, 26353931
K238 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
S471 O-Glycosylation GlyGen 30379171, 32114385, 34681736, ...19202066
S471 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
T559 Phosphorylation PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
T610 Phosphorylation PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K659 Acetylation PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
S670 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10195894
S672 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10195894, 18669648, 23186163, ...19690332
S675 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10195894, 23186163, 24275569
S679 Phosphorylation O14920 (IKBKB) PhosphoSitePlus   Signor 10195894
S682 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10195894
S689 Phosphorylation O14920 (IKBKB) phospho.ELM   Signor   UniProt 10195894
S692 Phosphorylation O14920 (IKBKB) phospho.ELM   Signor   UniProt 10195894
T693 Phosphorylation PhosphoSitePlus
S695 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10195894
S697 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10195894
K703 Ubiquitination PhosphoSitePlus
S705 Phosphorylation O14920 (IKBKB) phospho.ELM   Signor   UniProt 10195894
S733 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 32114385, 34681736, ...19202066
S733 Phosphorylation O14920 (IKBKB) , P53350 (PLK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10195894, 18957422, 19202066
T735 Phosphorylation PhosphoSitePlus
S740 Phosphorylation O14920 (IKBKB) , P53350 (PLK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10195894, 18957422
S750 Phosphorylation O14920 (IKBKB) , P53350 (PLK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10195894, 18957422
S756 Phosphorylation O14920 (IKBKB) Signor 10195894
Site PTM Type PTM Enzyme Score Source PMID
S177 Phosphorylation O43318 (MAP3K7) , Q99558 (MAP3K14) , Q05513 (PRKCZ) , Q04759 (PRKCQ) , O15111 (CHUK) HPRD 11460167, 9689078, 10195894, ...17363905, 10022904, 16286467, 10779355
C179 Phosphorylation O14920 (IKBKB) HPRD 16319058
S181 Phosphorylation O15111 (CHUK) , Q99558 (MAP3K14) , O43318 (MAP3K7) , Q05513 (PRKCZ) , Q04759 (PRKCQ) HPRD 11460167, 9689078, 10195894, ...17363905, 10022904, 16286467, 10779355
S670 Phosphorylation O14920 (IKBKB) HPRD 10195894, 20068231
S672 Phosphorylation O14920 (IKBKB) HPRD 19413330, 18691976, 10195894, ...19664994, 19651622, 18669648, 20068231
S675 Phosphorylation O14920 (IKBKB) HPRD 10195894, 20068231
S679 Phosphorylation O14920 (IKBKB) HPRD 10195894
S682 Phosphorylation O14920 (IKBKB) HPRD 10195894
S689 Phosphorylation O14920 (IKBKB) HPRD 10195894
S692 Phosphorylation O14920 (IKBKB) HPRD 10195894
S695 Phosphorylation O14920 (IKBKB) HPRD 10195894
S697 Phosphorylation O14920 (IKBKB) HPRD 10195894
S705 Phosphorylation O14920 (IKBKB) HPRD 10195894
S733 Phosphorylation O14920 (IKBKB) HPRD 10195894
S740 Phosphorylation O14920 (IKBKB) HPRD 10195894
S750 Phosphorylation O14920 (IKBKB) HPRD 10195894
S756 Phosphorylation O14920 (IKBKB) HPRD 10195894


O14920 (IKBKB) as PTM Enzyme



Substrate Site Score Source PMID
O14920-1 (IKBKB) C179 HPRD 16319058
O14920 (IKBKB) S181 RLIMS-P+ 24611898, 25195736, 24911653
O14920 (IKBKB) S670 HPRD   Signor   UniProt 10195894, 20068231
O14920-1 (IKBKB) S672 HPRD   Signor 19413330, 18691976, 10195894, ...19664994, 19651622, 18669648, 20068231
O14920 (IKBKB) S675 HPRD   Signor   UniProt 10195894, 20068231
O14920-1 (IKBKB) S679 HPRD   Signor 10195894
O14920 (IKBKB) S682 HPRD   Signor   UniProt 10195894
O14920 (IKBKB) S689 HPRD   Signor   UniProt 10195894
O14920 (IKBKB) S692 HPRD   Signor   UniProt 10195894
O14920-1 (IKBKB) S695 HPRD   Signor   UniProt 10195894
O14920-1 (IKBKB) S697 HPRD   Signor   UniProt 10195894
O14920 (IKBKB) S705 HPRD   Signor   UniProt 10195894
O14920 (IKBKB) S733 HPRD   Signor   UniProt 10195894
O14920-1 (IKBKB) S740 HPRD   Signor   UniProt 10195894
O14920-1 (IKBKB) S750 HPRD   Signor   UniProt 10195894
O14920 (IKBKB) S756 HPRD   Signor 10195894
O43524 (FOXO3) S644 neXtProt   PhosphoSitePlus   Signor 15084260, 19188143
O95999 (BCL10) S134 PhosphoSitePlus 16818229
P01100 (FOS) S308 PhosphoSitePlus 19285436
P04637 (TP53) S362 neXtProt 19196987
P04637 (TP53) S366 neXtProt 19196987
P19438 (TNFRSF1A) S381 PhosphoSitePlus 21724995
P19838 (NFKB1) S923 PhosphoSitePlus   Signor 10469655, 11158290
P19838-2 (NFKB1) S924 HPRD 10469655, 11158290
P19838 (NFKB1) S927 neXtProt   PhosphoSitePlus   Signor 11976329, 10469655, 11158290, ...10022904, 12482991, 11297557
P19838-2 (NFKB1) S928 HPRD 11976329
P19838 (NFKB1) S932 PhosphoSitePlus   Signor 12482991, 10469655, 11158290
P23396 (RPS3) S209 PhosphoSitePlus 21399639
P25963 (NFKBIA) S32 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+ 8601309, 17409387, 9214631, ...10823818, 9346484, 10723127, 9346485, 16319058, 9721103, 10882136
P25963 (NFKBIA) S36 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+ 8601309, 10823818, 17409387, ...9346485, 9346484, 10882136, 9721103, 10783893
P31946 (YWHAB) S132 Signor 16024783
P35568 (IRS1) S268 HPRD 12351658
P35568 (IRS1) S270 HPRD 19651622, 18077418, 12351658
P35568 (IRS1) S272 HPRD 12351658
P35568 (IRS1) S274 HPRD 12351658
P35568 (IRS1) S307 HPRD 12351658
P35568 (IRS1) S312 HPRD   neXtProt   PhosphoSitePlus 12351658, 11606564, 10722755
P35568 (IRS1) S341 HPRD 12351658
P35568 (IRS1) S345 HPRD 12351658
P35568 (IRS1) S527 HPRD 19651622, 12351658
P35568 (IRS1) S531 HPRD 19651622, 12351658
P42771 (CDKN2A) S8 PhosphoSitePlus   Signor 20152798
Q01201 (RELB) S472 PhosphoSitePlus 25267645
Q04206 (RELA) S468 PhosphoSitePlus   Signor 16046471
Q04206 (RELA) S536 PhosphoSitePlus   Signor 15611068, 15192014, 26693062, ...20410276, 15128824, 15489227, 16046471, 12759443
Q04864 (REL) S557 PhosphoSitePlus 17072339
Q13568 (IRF5) S446 PhosphoSitePlus 25326418
Q14164 (IKBKE) S172 neXtProt 21138416
Q14653 (IRF3) S396 PhosphoSitePlus 19153595
Q14653 (IRF3) S398 PhosphoSitePlus 19153595
Q14653 (IRF3) S402 PhosphoSitePlus 19153595
Q14653 (IRF3) T404 PhosphoSitePlus 19153595
Q14653 (IRF3) S405 PhosphoSitePlus 19153595
Q15653 (NFKBIB) S19 HPRD   neXtProt 9346484, 9520401, 8657102, ...9689078
Q15653-1 (NFKBIB) S23 HPRD   neXtProt 9346484, 8657102, 9520401, ...9689078
Q16875 (PFKFB3) S269 RLIMS-P+ 27585591
Q5S007 (LRRK2) S910 neXtProt 22723946
Q5S007 (LRRK2) S935 neXtProt 22723946
Q92574 (TSC1) S487 neXtProt   PhosphoSitePlus   Signor 17693255, 19188143
Q92574 (TSC1) S511 neXtProt   PhosphoSitePlus   Signor 17693255, 19188143, 24135021
Q96CV9 (OPTN) S513 PhosphoSitePlus 21862579
Q99704 (DOK1) S439 neXtProt   PhosphoSitePlus   Signor 15574499
Q99704 (DOK1) S443 neXtProt   PhosphoSitePlus   Signor 15574499
Q99704 (DOK1) S446 neXtProt   PhosphoSitePlus   Signor 15574499
Q99704 (DOK1) S450 neXtProt   PhosphoSitePlus   Signor 15574499
Q9BXH1 (BBC3) S10 PhosphoSitePlus 21997190
Q9H3D4 (TP63) S43 PhosphoSitePlus 23589370
Q9H3D4 (TP63) S51 PhosphoSitePlus 23589370
Q9H765 (ASB8) S31 Signor 31009856
Q9NQC7 (CYLD) S418 PhosphoSitePlus   Signor 24614225, 15870263
Q9NQC7 (CYLD) S422 PhosphoSitePlus   Signor 24614225, 15870263
Q9NQC7 (CYLD) S432 PhosphoSitePlus   Signor 24614225, 15870263
Q9NQC7 (CYLD) S436 PhosphoSitePlus   Signor 24614225, 15870263
Q9NQC7 (CYLD) S439 PhosphoSitePlus   Signor 24614225, 15870263
Q9NQC7 (CYLD) S441 PhosphoSitePlus   Signor 24614225, 15870263
Q9NQC7 (CYLD) S444 PhosphoSitePlus   Signor 24614225, 15870263
Q9Y4G8 (RAPGEF2) S1254 PhosphoSitePlus 24290981
Q9Y6K9-1 (IKBKG) S31 HPRD   PhosphoSitePlus   Signor 12657630
Q9Y6K9 (IKBKG) S43 HPRD   PhosphoSitePlus   Signor 12657630, 17977820
Q9Y6K9 (IKBKG) S68 PhosphoSitePlus   Signor 17977820
Q9Y6K9 (IKBKG) S85 PhosphoSitePlus   Signor 17977820
Q9Y6K9 (IKBKG) S376 HPRD   PhosphoSitePlus   Signor 18691976, 12657630
Q9Y6Q9-1 (NCOA3) S857 HPRD 19413330, 16964243, 16135815, ...15302935, 19651622, 18669648, 15383283, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035831 (hIKBKB/Phos:1) pS177,pS181 PR:000035736 (hMAP3K7/Phos:1) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K171 R171 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
K171 Q171 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K171 T171 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K171 E171 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K171 M171 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S181 L181 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y188 C188 Biomuta DOID:4159 / skin cancer [ cosmic ]
S256 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S258 Y258 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y261 C261 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S267 N267 Biomuta DOID:1612 / breast cancer [ cosmic ]
K301 N301 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K337 N337 Biomuta DOID:363 / uterine cancer [ icgc ]
T368 S368 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S402 F402 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S471 F471 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S489 N489 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T583 N583 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S587 C587 Biomuta DOID:1324 / lung cancer [ cosmic ]
S600 N600 Biomuta DOID:3571 / liver cancer [ cosmic ]
K603 R603 Biomuta DOID:1324 / lung cancer [ cosmic ]
T610 M610 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S679 F679 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S689 C689 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S689 F689 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T693 A693 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T693 M693 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K703 E703 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K703 N703 Biomuta DOID:1319 / brain cancer [ icgc ]