iPTMnet Report for O14896 (IRF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14896 / IRF6_HUMAN
Protein Name Interferon regulatory factor 6
Gene Name Name: IRF6
Organism Homo sapiens (Human)

PRO ID PR:O14896
DAG View
PRO Name interferon regulatory factor 6 (human)
Definition An interferon regulatory factor 6 that is encoded in the genome of human.
Short Label hIRF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14896 (IRF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S33 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
Y97 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 Y33 Biomuta DOID:1319 / brain cancer [ icgc ]
K66 * Biomuta [ cosmic ]
Y97 C97 Biomuta DOID:3571 / liver cancer [ cosmic ]
S122 W122 Biomuta DOID:363 / uterine cancer [ icgc ]
S122 T122 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S122 L122 Biomuta DOID:363 / uterine cancer [ icgc ]
S407 F407 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S413 F413 Biomuta DOID:4159 / skin cancer [ cosmic ]
S424 L424 Biomuta DOID:4159 / skin cancer [ cosmic ]
S424 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S424 A424 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]