iPTMnet Report for O14879 (IFIT3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14879 / IFIT3_HUMAN
Protein Name Interferon-induced protein with tetratricopeptide repeats 3
Gene Name Name: IFIT3
Synonyms:CIG-49,IFI60,IFIT4,ISG60;
Organism Homo sapiens (Human)

PRO ID PR:O14879
DAG View
PRO Name interferon-induced protein with tetratricopeptide repeats 3 (human)
Definition An interferon-induced protein with tetratricopeptide repeats 3 that is encoded in the genome of human.
Short Label hIFIT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14879 (IFIT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
C39 Methylation IEDB 31844290
Y54 Phosphorylation PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
C158 Methylation IEDB 31844290
K161 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
S192 Phosphorylation HPRD 20068231
T193 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K197 Ubiquitination PhosphoSitePlus
S203 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 16964243, ...20068231
Y208 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
S237 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
C239 Methylation IEDB 31844290
K249 Acetylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
T295 O-Glycosylation GlyGen 30379171, 29351928
S298 O-Glycosylation GlyGen 30379171, 29351928
K311 Ubiquitination PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
S477 Phosphorylation HPRD   phospho.ELM 18669648
S478 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S486 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 F8 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C39 G39 Biomuta DOID:1319 / brain cancer [ icgc ]
K126 Q126 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S237 Y237 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K324 N324 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K373 N373 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K436 E436 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S486 * Biomuta DOID:1324 / lung cancer [ cosmic ]