Protein Information

Cytoscape View


UniProt AC / UniProt ID O14874 / BCKD_HUMAN
Protein Name [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor
Gene Name Name: BCKDK
Organism Homo sapiens (Human)

PRO ID PR:O14874
DAG View
PRO Name [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (human)
Definition A [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial that is encoded in the genome of human.
Short Label hBCKDK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14874 (BCKDK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T32 Phosphorylation PhosphoSitePlus
S33 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T35 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
K89 Methylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K184 Acetylation PhosphoSitePlus
K192 Acetylation PhosphoSitePlus   UniProt 19608861
K233 Acetylation PhosphoSitePlus   UniProt 19608861
K245 Acetylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus   RLIMS-P 32238881
S356 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation HPRD 18691976, 17081983, 18452278, ...19651622, 20166139, 20068231
T32 Phosphorylation HPRD 17081983, 20068231
S33 Phosphorylation HPRD 17081983, 20068231, 18452278
T35 Phosphorylation HPRD 20166139, 20068231, 18452278


O14874 (BCKDK) as PTM Enzyme



Substrate Site Score Source PMID
P12694 (BCKDHA) S337 Signor 3947057


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y77 C77 Biomuta DOID:9256 / colorectal cancer [ icgc ]