iPTMnet Report O14874 BCKDK

Protein Information

Cytoscape View

UniProt AC / UniProt ID	O14874 / BCKD_HUMAN
Protein Name	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor
Gene Name	Name: BCKDK
Organism	Homo sapiens (Human)

PRO ID	PR:O14874 DAG View
PRO Name	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (human)
Definition	A [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial that is encoded in the genome of human.
Short Label	hBCKDK
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O14874 (BCKDK) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S31	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P	32457292, 18220336
	T32	Phosphorylation		score1	PhosphoSitePlus
	S33	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18220336
	T35	Phosphorylation		score1	PhosphoSitePlus
	T37	Phosphorylation		score1	PhosphoSitePlus
	S47	Phosphorylation		score1	PhosphoSitePlus
	K48	Ubiquitination		score1	PhosphoSitePlus
	S52	Phosphorylation		score1	PhosphoSitePlus
	Y77	Phosphorylation		score1	PhosphoSitePlus
	K89	Methylation		score1	PhosphoSitePlus
	Y93	Phosphorylation		score1	PhosphoSitePlus
	K184	Acetylation		score1	PhosphoSitePlus
	K192	Acetylation		score2	PhosphoSitePlus UniProt	19608861
	K233	Acetylation		score2	PhosphoSitePlus UniProt	19608861
	K245	Acetylation		score1	PhosphoSitePlus
	Y246	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	32238881
	S356	Phosphorylation		score1	PhosphoSitePlus
	S360	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S31	Phosphorylation		score0	HPRD	18691976, 17081983, 18452278, ...19651622, 20166139, 20068231
	T32	Phosphorylation		score0	HPRD	17081983, 20068231
	S33	Phosphorylation		score0	HPRD	17081983, 20068231, 18452278
	T35	Phosphorylation		score0	HPRD	20166139, 20068231, 18452278

O14874 (BCKDK) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P12694 (BCKDHA)	S337	score1	Signor	3947057

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S52	P52	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
Y77	C77	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
K184	N184	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
K245	N245	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S360	L360	Biomuta		DOID:4159 / skin cancer [ cosmic ]