Protein Information

Cytoscape View


UniProt AC / UniProt ID O14802 / RPC1_HUMAN
Protein Name DNA-directed RNA polymerase III subunit RPC1
Gene Name Name: POLR3A
Organism Homo sapiens (Human)

PRO ID PR:O14802
DAG View
PRO Name DNA-directed RNA polymerase III subunit RPC1 (human)
Definition A DNA-directed RNA polymerase III subunit RPC1 that is encoded in the genome of human.
Short Label hPOLR3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14802 (POLR3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Methylation PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K346 Acetylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
R353 Methylation PhosphoSitePlus
K359 Acetylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
Y434 Phosphorylation HPRD   PhosphoSitePlus 20068231
K445 Acetylation PhosphoSitePlus   UniProt 19608861
K445 Ubiquitination PhosphoSitePlus
T525 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
Y714 Phosphorylation PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
K877 Ubiquitination PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus
S936 Phosphorylation HPRD 18767875
S941 Phosphorylation HPRD 18767875
T948 Phosphorylation PhosphoSitePlus
T949 Phosphorylation PhosphoSitePlus
K955 Ubiquitination PhosphoSitePlus
K970 Ubiquitination PhosphoSitePlus
K974 Ubiquitination PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
K986 Ubiquitination PhosphoSitePlus
R1005 Methylation PhosphoSitePlus
K1013 Ubiquitination PhosphoSitePlus
T1046 Phosphorylation HPRD   PhosphoSitePlus 18077418
T1049 Phosphorylation HPRD   PhosphoSitePlus 18077418
K1071 Ubiquitination PhosphoSitePlus
K1078 Ubiquitination PhosphoSitePlus
K1091 Ubiquitination PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
K1157 Ubiquitination PhosphoSitePlus
S1181 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1182 Ubiquitination PhosphoSitePlus
K1198 Ubiquitination PhosphoSitePlus
K1224 Ubiquitination PhosphoSitePlus
T1238 Phosphorylation PhosphoSitePlus
K1242 Ubiquitination PhosphoSitePlus
T1244 Phosphorylation PhosphoSitePlus
T1247 Phosphorylation PhosphoSitePlus
T1251 Phosphorylation PhosphoSitePlus
K1256 Ubiquitination PhosphoSitePlus
T1304 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1365 Acetylation PhosphoSitePlus
K1365 Ubiquitination PhosphoSitePlus
K1374 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T525 N525 Biomuta DOID:1909 / melanoma [ cosmic ]
K735 T735 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S977 F977 Biomuta DOID:1612 / breast cancer [ cosmic ]
R1005 H1005 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:1115 / sarcoma [ tcga ]
T1046 I1046 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K1078 N1078 Biomuta DOID:363 / uterine cancer [ tcga ]
K1198 N1198 Biomuta DOID:0070003 / blastoma [ cosmic ]
T1238 R1238 Biomuta DOID:263 / kidney cancer [ tcga ]