iPTMnet Report for O14777 (NDC80)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14777 / NDC80_HUMAN
Protein Name Kinetochore protein NDC80 homolog
Gene Name Name: NDC80
Synonyms:HEC,HEC1,KNTC2;
Organism Homo sapiens (Human)

PRO ID PR:O14777
DAG View
PRO Name kinetochore protein NDC80 (human)
Definition A kinetochore protein NDC80 that is encoded in the genome of human.
Short Label hNDC80
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14777 (NDC80) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus   Signor 20471944, 17129782
S5 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus   Signor 20471944, 17129782
S7 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   Signor 20471944, 17129782
S15 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus   Signor 20471944, 17129782
R20 Methylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
Y30 Phosphorylation PhosphoSitePlus
T31 Phosphorylation HPRD   PhosphoSitePlus 19007248
T34 Phosphorylation HPRD 19007248
K37 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S44 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32027339, 23186163, 20471944, ...19007248, 29187526
S44 Phosphorylation Q96GD4 (AURKB) Signor 20471944
K47 Ubiquitination PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus 17129782
T49 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 17129782
S50 Phosphorylation HPRD   PhosphoSitePlus 19691289
K53 Acetylation PhosphoSitePlus   UniProt 30409912
S55 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 25987563, 30409912, 35638575, ...19691289, 16565220, 26166783, 19007248, 17129782, 29187526, 33377866, 29142109, 33988677
S55 Phosphorylation O14965 (AURKA) PhosphoSitePlus 26166783
S55 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 25987563, 17129782
K59 Acetylation PhosphoSitePlus   UniProt 30409912
K59 Methylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
S62 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 30409912, 20068231, 16565220
S66 Phosphorylation HPRD   PhosphoSitePlus 20068231
S69 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 32401635, 23186163, 19664994, ...19007248, 19691289, 17129782, 29187526, 33988677, 20068231
S69 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 17129782
S75 Phosphorylation PhosphoSitePlus
S76 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16565220
S77 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19691289, 20068231, 16565220
K81 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
C95 Methylation IEDB 31844290
K123 Ubiquitination PhosphoSitePlus
R153 Methylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
S165 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24662830, 12386167, 21832156, ...27764815, 26595804, 18297113
S165 Phosphorylation P51955 (NEK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12386167, 18297113, 21832156
S165 Phosphorylation Q96PY6 (NEK1) PhosphoSitePlus 12386167
S202 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
C342 Methylation IEDB 31844290
K346 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
Y458 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
T502 Phosphorylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
K527 Acetylation PhosphoSitePlus   UniProt 30409912
S530 Phosphorylation PhosphoSitePlus
T572 Phosphorylation IEDB 35494241
T591 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
T635 Phosphorylation IEDB 35494241


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y2Z0 (SUGT1) S331 O14777 (NDC80) unknown eFIP 22869522


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O14777 (hNDC80) Interaction PR:Q9BZD4 (hNUF2) PRO
PR:O14777 (hNDC80) Interaction PR:Q8NG31 (hKNL1) PRO
PR:Q8NG31 (hKNL1) Interaction PR:O14777 (hNDC80) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T31 I31 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T31 A31 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K42 N42 Biomuta DOID:3571 / liver cancer [ cosmic ]
S62 N62 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S69 C69 Biomuta DOID:1324 / lung cancer [ cosmic ]
R153 K153 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S202 L202 Biomuta DOID:1319 / brain cancer [ cosmic ]
K253 R253 Biomuta DOID:263 / kidney cancer [ cosmic ]
T591 A591 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K606 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S616 * Biomuta [ cosmic ]