iPTMnet Report O14773 TPP1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	O14773 / TPP1_HUMAN
Protein Name	Tripeptidyl-peptidase 1 precursor
Gene Name	Name: TPP1 Synonyms:CLN2;ORFNames:GIG1,UNQ267/PRO304;
Organism	Homo sapiens (Human)

PRO ID	PR:O14773 DAG View
PRO Name	tripeptidyl-peptidase 1 (human)
Definition	A tripeptidyl-peptidase 1 that is encoded in the genome of human.
Short Label	hTPP1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O14773 (TPP1) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T193	O-Glycosylation		score1	GlyGen	25813380
	T201	Phosphorylation	P06493 (CDK1)	score1	PhosphoSitePlus	18234856
	N210	N-Glycosylation		score4	GlyGen UniProt	19159218, 24190977, 19038966, ...29741879, 29671580, 19038967, 14702339
	N222	N-Glycosylation		score4	GlyGen UniProt	14702339, 19159218, 24190977
	N223	N-Glycosylation		score1	GlyGen	24190977
	S256	Phosphorylation		score1	PhosphoSitePlus
	N286	N-Glycosylation		score4	GlyGen UniProt	19038966, 19038967, 14702339
	N313	N-Glycosylation		score4	GlyGen UniProt	29741879, 19038966, 19038967, ...19159218, 14702339
	K428	Sumoylation		score1	PhosphoSitePlus
	N443	N-Glycosylation		score4	GlyGen UniProt	19159218, 24190977, 23090970, ...29741879, 12754519, 19038966, 19038967, 14702339
	Y459	Phosphorylation		score1	PhosphoSitePlus
	T478	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	N210	N-Glycosylation		score1	PRO	29671580

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
N443	S443	Biomuta		DOID:1324 / lung cancer [ cosmic ]