iPTMnet Report for O14745 (NHERF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14745 / NHRF1_HUMAN
Protein Name Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Gene Name Name: NHERF1
Synonyms:NHERF,SLC9A3R1;
Organism Homo sapiens (Human)

PRO ID PR:O14745
DAG View
PRO Name Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human)
Definition A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of human.
Short Label hSLC9A3R1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14745 (NHERF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
C15 S-Nitrosylation dbSNO 24105792
C16 S-Nitrosylation dbSNO 24105792
K19 Acetylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K50 Ubiquitination PhosphoSitePlus
R58 Methylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus   RLIMS-P 20571032
S77 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 20571032
T95 Phosphorylation PhosphoSitePlus   RLIMS-P 20571032
K101 Ubiquitination PhosphoSitePlus
R107 Methylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus   RLIMS-P+   RLIMS-P 26862730, 25492869
T156 Phosphorylation P31749 (AKT1) RLIMS-P+ 25492869
S162 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 22801783, 17613530, ...12881487
S162 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 17613530, 12881487
Y164 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
C206 Methylation IEDB 31844290
C206 S-Nitrosylation dbSNO 24105792
S217 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
S269 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 24275569
S280 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18088087, 17081983, ...18220336, 20937695, 23775624, 24275569, 23186163, 20068231, 17924679
S280 Phosphorylation P06493 (CDK1) PhosphoSitePlus 23775624
S288 Phosphorylation PhosphoSitePlus
S290 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18088087, 15302935, 33499384, ...10446210, 20937695, 18669648
S290 Phosphorylation P43250 (GRK6) neXtProt   Signor 10446210
S291 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18088087, 20937695
T293 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
S294 Phosphorylation PhosphoSitePlus   UniProt 24275569
S299 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus   RLIMS-P 23775624, 20937695
S302 Phosphorylation P06493 (CDK1) PhosphoSitePlus 23775624
S313 Phosphorylation PhosphoSitePlus
S316 Phosphorylation phospho.ELM 18669648
S317 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus   RLIMS-P 17613530, 22801783
S339 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 17613530
S340 Phosphorylation PhosphoSitePlus   RLIMS-P 17613530, 22801783
S340 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 17613530
S349 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19413330
S46 Phosphorylation HPRD 18669648, 20068231
S269 Phosphorylation HPRD 19651622, 17081983
S280 Phosphorylation HPRD 17081983, 18088087, 18212344, ...18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231, 17924679
S288 Phosphorylation HPRD 19664995, 18452278, 19651622, ...18669648, 20166139, 20068231
S290 Phosphorylation HPRD 19413330, 18088087, 15302935, ...19664995, 18452278, 18669648, 20166139
S290 Phosphorylation P43250 (GRK6) HPRD 19413330, 18088087, 15302935, ...19664995, 18452278, 18669648, 20166139
S291 Phosphorylation HPRD 19413330, 18088087, 20058876, ...19664995, 19651622, 18669648, 20166139, 20068231
T293 Phosphorylation HPRD 19651622, 18088087, 20058876, ...20068231
S294 Phosphorylation HPRD 18669648, 19664994
S299 Phosphorylation HPRD 19664994, 20068231
S302 Phosphorylation HPRD 18669648, 19664994
S317 Phosphorylation HPRD 18669648
S326 Phosphorylation HPRD 20068231


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000049847 (hPDGFRB/SigPep-/Phos:3) decreased Interaction PR:O14745 (hSLC9A3R1) PRO 15271984
PR:P35240-1 (hNF2/iso:1) Interaction PR:O14745 (hSLC9A3R1) PRO 9430655


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y38 H38 Biomuta DOID:1612 / breast cancer [ cosmic ]
K50 N50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K101 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T293 I293 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S294 G294 Biomuta DOID:263 / kidney cancer [ cosmic ]
S299 Y299 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S302 T302 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S316 F316 Biomuta DOID:4159 / skin cancer [ cosmic ]
K350 N350 Biomuta DOID:5041 / esophageal cancer [ cosmic ]