iPTMnet Report for O14734 (ACOT8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14734 / ACOT8_HUMAN
Protein Name Acyl-coenzyme A thioesterase 8
Gene Name Name: ACOT8
Synonyms:ACTEIII,PTE1;
Organism Homo sapiens (Human)

PRO ID PR:O14734
DAG View
PRO Name acyl-coenzyme A thioesterase 8 (human)
Definition An acyl-coenzyme A thioesterase 8 that is encoded in the genome of human.
Short Label hACOT8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14734 (ACOT8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD   PhosphoSitePlus 18691976
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
K311 Acetylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
K318 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K52 R52 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K169 N169 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S315 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S317 R317 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S317 I317 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]