Protein Information

Cytoscape View


UniProt AC / UniProt ID O14733 / MP2K7_HUMAN
Protein Name Dual specificity mitogen-activated protein kinase kinase 7
Gene Name Name: MAP2K7
Synonyms:JNKK2,MEK7,MKK7,PRKMK7,SKK4;
Organism Homo sapiens (Human)

PRO ID PR:O14733
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 7 (human)
Definition A dual specificity mitogen-activated protein kinase kinase 7 that is encoded in the genome of human.
Short Label hMAP2K7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14733 (MAP2K7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S4 Phosphorylation RLIMS-P 15358159
K9 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S271 Phosphorylation Q9Y2U5 (MAP3K2) , Q13233 (MAP3K1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 9312068, 17110930, 10347227, ...22903704, 10713157
T275 Phosphorylation Q9Y2U5 (MAP3K2) , Q13233 (MAP3K1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 9312068, 17110930, 10347227, ...22903704, 10713157
S277 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
S307 Phosphorylation RLIMS-P 23566306
K326 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus   RLIMS-P 27034005
S403 Phosphorylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 20068231
S86 Phosphorylation HPRD 20068231
S89 Phosphorylation HPRD 20068231


O14733 (MAP2K7) as PTM Enzyme



Substrate Site Score Source PMID
P35568 (IRS1) S312 Signor 17360977
P45983-2 (MAPK8) T183 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18691976, 11390361, 9207092, ...9312068, 18436711, 18669648, 11062067, 11971971, 15911620
P45983 (MAPK8) Y185 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11390361, 9207092, 9312068, ...18436711, 11062067, 11971971
P45984-2 (MAPK9) T183 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9890973, 15911620, 11062067
P45984-4 (MAPK9) Y185 HPRD   Signor 11062067
P45984 (MAPK9) T404 HPRD   phospho.ELM   PhosphoSitePlus 11062067
P45984-1 (MAPK9) S407 HPRD   phospho.ELM   PhosphoSitePlus 11062067
P53779 (MAPK10) T221 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11062067, 15911620
Q13158 (FADD) S194 PhosphoSitePlus   Signor 15001534
Q16539 (MAPK14) Y182 neXtProt 11062067


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048301 (hMAP2K7/Phos:1) pS271,pT275 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:1909 / melanoma [ cosmic ]
S86 I86 Biomuta DOID:3571 / liver cancer [ icgc ]
K95 R95 Biomuta DOID:263 / kidney cancer [ tcga ]
K221 R221 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S265 R265 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S271 T271 Biomuta DOID:1909 / melanoma [ cosmic ]
T275 M275 Biomuta DOID:10534 / stomach cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S277 C277 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S378 I378 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]