iPTMnet Report for O14730 (RIOK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14730 / RIOK3_HUMAN
Protein Name Serine/threonine-protein kinase RIO3
Gene Name Name: RIOK3
Synonyms:SUDD;
Organism Homo sapiens (Human)

PRO ID PR:O14730
DAG View
PRO Name serine/threonine-protein kinase RIO3 (human)
Definition A serine/threonine-protein kinase RIO3 that is encoded in the genome of human.
Short Label hRIOK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14730 (RIOK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus   UniProt 23186163
K21 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y116 Phosphorylation PhosphoSitePlus
Y122 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S125 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S127 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S128 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y142 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
C346 Methylation IEDB 31844290
K376 Ubiquitination PhosphoSitePlus
C400 Methylation IEDB 31844290
K452 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
Y517 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y122 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S125 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S127 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
S128 Phosphorylation HPRD 19651622, 18669648, 17081983


O14730 (RIOK3) as PTM Enzyme



Substrate Site Score Source PMID
Q9BYX4 (IFIH1) S828 PhosphoSitePlus   Signor 25865883


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 L8 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S107 N107 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S107 G107 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S110 F110 Biomuta DOID:4159 / skin cancer [ cosmic ]
S112 F112 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S127 R127 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K207 T207 Biomuta DOID:1612 / breast cancer [ cosmic ]
K290 E290 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K300 N300 Biomuta DOID:363 / uterine cancer [ icgc ]
K456 Q456 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K502 N502 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]