iPTMnet Report for O14727 (APAF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14727 / APAF_HUMAN
Protein Name Apoptotic protease-activating factor 1
Gene Name Name: APAF1
Synonyms:KIAA0413;
Organism Homo sapiens (Human)

PRO ID PR:O14727
DAG View
PRO Name apoptotic protease-activating factor 1 (human)
Definition An apoptotic protease-activating factor 1 that is encoded in the genome of human.
Short Label hAPAF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14727 (APAF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y24 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
T204 Phosphorylation phospho.ELM 17081983
K224 Ubiquitination PhosphoSitePlus
S238 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S248 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K267 Ubiquitination PhosphoSitePlus
S268 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus   RLIMS-P 22246185, 29511177
S272 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S357 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus 22246185
S369 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
K643 Acetylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
K654 Acetylation PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
T905 Phosphorylation PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
K1048 Ubiquitination PhosphoSitePlus
K1077 Ubiquitination PhosphoSitePlus
K1079 Ubiquitination PhosphoSitePlus
K1099 Ubiquitination PhosphoSitePlus
T1103 Phosphorylation PhosphoSitePlus
K1107 Ubiquitination PhosphoSitePlus
T1108 Phosphorylation PhosphoSitePlus
K1222 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T204 Phosphorylation HPRD 17081983
S238 Phosphorylation HPRD 17081983, 20068231
S248 Phosphorylation HPRD 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T193 Phosphorylation HPRD 17081983
S227 Phosphorylation HPRD 17081983, 20068231
S237 Phosphorylation HPRD 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T193 Phosphorylation HPRD 17081983
S227 Phosphorylation HPRD 17081983, 20068231
S237 Phosphorylation HPRD 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T204 Phosphorylation HPRD 17081983
S238 Phosphorylation HPRD 17081983, 20068231
S248 Phosphorylation HPRD 17081983, 20068231
K820 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T204 Phosphorylation HPRD 17081983
S238 Phosphorylation HPRD 17081983, 20068231
S248 Phosphorylation HPRD 17081983, 20068231


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P99999-1 (hCYCS/iso:1) Interaction PR:O14727-3 (hAPAF1/iso:3) PRO 9267021


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S31 N31 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K131 M131 Biomuta DOID:1324 / lung cancer [ cosmic ]
S161 C161 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K192 E192 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K192 T192 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S227 F227 Biomuta DOID:8618 / oral cavity cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:11934 / head and neck cancer [ icgc, icgc, icgc, icgc ]
S238 F238 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S272 L272 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S369 F369 Biomuta DOID:363 / uterine cancer [ icgc ]
S371 C371 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K391 N391 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K600 T600 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K600 R600 Biomuta DOID:263 / kidney cancer [ cosmic ]
K637 T637 Biomuta DOID:363 / uterine cancer [ icgc ]
K1099 T1099 Biomuta DOID:363 / uterine cancer [ icgc ]