Protein Information

Cytoscape View


UniProt AC / UniProt ID O14686 / KMT2D_HUMAN
Protein Name Histone-lysine N-methyltransferase 2D
Gene Name Name: KMT2D
Synonyms:ALR,MLL2,MLL4;
Organism Homo sapiens (Human)

PRO ID PR:O14686
DAG View
PRO Name histone-lysine N-methyltransferase 2D (human)
Definition A histone-lysine N-methyltransferase 2D that is encoded in the genome of human.
Short Label hKMT2D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14686 (KMT2D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus   UniProt 18669648
T29 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
T380 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
S952 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1164 Phosphorylation PhosphoSitePlus
S1180 Phosphorylation PhosphoSitePlus
T1195 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1198 Phosphorylation PhosphoSitePlus
S1249 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1263 Phosphorylation PhosphoSitePlus
T1267 Phosphorylation PhosphoSitePlus
S1270 Phosphorylation PhosphoSitePlus
S1293 Phosphorylation PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus
S1298 Phosphorylation PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
S1331 Phosphorylation PhosphoSitePlus
T1332 Phosphorylation PhosphoSitePlus
S1334 Phosphorylation PhosphoSitePlus
S1335 Phosphorylation PhosphoSitePlus
S1606 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K1610 Ubiquitination PhosphoSitePlus
T1647 Phosphorylation PhosphoSitePlus
S1671 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
K1690 Acetylation PhosphoSitePlus
Y1692 Phosphorylation PhosphoSitePlus
S1722 Phosphorylation PhosphoSitePlus
S1762 Phosphorylation PhosphoSitePlus
S1798 Phosphorylation PhosphoSitePlus
T1803 Phosphorylation PhosphoSitePlus
K1815 Acetylation PhosphoSitePlus
T1819 Phosphorylation PhosphoSitePlus
S1820 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1822 Acetylation PhosphoSitePlus
S1834 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1843 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1854 Phosphorylation PhosphoSitePlus
S1858 Phosphorylation PhosphoSitePlus
T1865 Phosphorylation PhosphoSitePlus
S1872 Phosphorylation PhosphoSitePlus
K1896 Ubiquitination PhosphoSitePlus
T1911 Phosphorylation PhosphoSitePlus
S1950 Phosphorylation PhosphoSitePlus
T2097 Phosphorylation PhosphoSitePlus
S2128 Phosphorylation PhosphoSitePlus
T2131 Phosphorylation PhosphoSitePlus
S2155 Phosphorylation PhosphoSitePlus
S2201 Phosphorylation PhosphoSitePlus
T2228 Phosphorylation PhosphoSitePlus
T2229 Phosphorylation PhosphoSitePlus
T2233 Phosphorylation PhosphoSitePlus
S2239 Phosphorylation PhosphoSitePlus   UniProt 24275569
T2240 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2246 Acetylation PhosphoSitePlus   UniProt 19608861
S2251 Phosphorylation PhosphoSitePlus
S2260 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2274 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
S2295 Phosphorylation PhosphoSitePlus
S2296 Phosphorylation PhosphoSitePlus
S2298 Phosphorylation PhosphoSitePlus
Y2299 Phosphorylation PhosphoSitePlus
S2309 Phosphorylation PhosphoSitePlus   UniProt 18669648
S2311 Phosphorylation PhosphoSitePlus   UniProt 18669648
T2314 Phosphorylation PhosphoSitePlus
T2323 Phosphorylation PhosphoSitePlus
T2332 Phosphorylation PhosphoSitePlus
S2342 Phosphorylation PhosphoSitePlus
T2426 Phosphorylation PhosphoSitePlus
S2451 Phosphorylation phospho.ELM 18669648
K2468 Acetylation PhosphoSitePlus
R2471 Methylation PhosphoSitePlus
S2512 Phosphorylation PhosphoSitePlus
S2636 Phosphorylation PhosphoSitePlus
S2640 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2725 Phosphorylation PhosphoSitePlus
S2726 Phosphorylation PhosphoSitePlus
S2733 Phosphorylation PhosphoSitePlus
T2742 Phosphorylation PhosphoSitePlus
K2755 Acetylation PhosphoSitePlus
R2774 Methylation PhosphoSitePlus
R2860 Methylation PhosphoSitePlus
R2881 Methylation PhosphoSitePlus
K2886 Methylation PhosphoSitePlus
R2903 Methylation PhosphoSitePlus
R2905 Methylation PhosphoSitePlus
R2915 Methylation PhosphoSitePlus
R2922 Methylation PhosphoSitePlus
T2949 Phosphorylation PhosphoSitePlus
S2969 Phosphorylation PhosphoSitePlus
K3079 Acetylation PhosphoSitePlus   UniProt 19608861
K3119 Acetylation PhosphoSitePlus
K3121 Acetylation PhosphoSitePlus
S3130 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983
T3138 Phosphorylation PhosphoSitePlus
K3155 Acetylation PhosphoSitePlus
T3179 Phosphorylation PhosphoSitePlus
K3182 Acetylation PhosphoSitePlus
T3197 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S3199 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S3202 Phosphorylation PhosphoSitePlus
S3229 Phosphorylation PhosphoSitePlus
K3433 Acetylation PhosphoSitePlus   UniProt 19608861
S3443 Phosphorylation PhosphoSitePlus
S3463 Phosphorylation PhosphoSitePlus
S3620 Phosphorylation PhosphoSitePlus
S3624 Phosphorylation PhosphoSitePlus
R3626 Methylation PhosphoSitePlus
R3719 Methylation PhosphoSitePlus
R3727 Methylation PhosphoSitePlus   UniProt 24129315
S3832 Phosphorylation PhosphoSitePlus
S3836 Phosphorylation PhosphoSitePlus
S3837 Phosphorylation PhosphoSitePlus
R3851 Methylation PhosphoSitePlus
S3986 Phosphorylation PhosphoSitePlus
K4004 Acetylation PhosphoSitePlus
S4011 Phosphorylation PhosphoSitePlus
R4212 Methylation PhosphoSitePlus
S4215 Phosphorylation PhosphoSitePlus   UniProt 20068231
S4359 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 20068231
S4430 Phosphorylation PhosphoSitePlus
S4456 Phosphorylation PhosphoSitePlus
K4465 Acetylation PhosphoSitePlus   UniProt 19608861
K4465 Ubiquitination PhosphoSitePlus
K4470 Ubiquitination PhosphoSitePlus
S4475 Phosphorylation PhosphoSitePlus
K4501 Ubiquitination PhosphoSitePlus
T4505 Phosphorylation PhosphoSitePlus
K4509 Acetylation PhosphoSitePlus
K4516 Acetylation PhosphoSitePlus
T4519 Phosphorylation PhosphoSitePlus
S4534 Phosphorylation PhosphoSitePlus
K4553 Ubiquitination PhosphoSitePlus
S4617 Phosphorylation PhosphoSitePlus
T4621 Phosphorylation PhosphoSitePlus
S4624 Phosphorylation PhosphoSitePlus
S4625 Phosphorylation PhosphoSitePlus
T4629 Phosphorylation PhosphoSitePlus
S4633 Phosphorylation PhosphoSitePlus
T4643 Phosphorylation PhosphoSitePlus
S4661 Phosphorylation PhosphoSitePlus
T4682 Phosphorylation PhosphoSitePlus
T4688 Phosphorylation PhosphoSitePlus
S4727 Phosphorylation PhosphoSitePlus
S4738 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...24275569, 20068231
K4756 Acetylation PhosphoSitePlus
K4756 Sumoylation PhosphoSitePlus
K4776 Acetylation PhosphoSitePlus   UniProt 19608861
S4780 Phosphorylation PhosphoSitePlus
S4783 Phosphorylation PhosphoSitePlus
T4787 Phosphorylation PhosphoSitePlus
S4789 Phosphorylation PhosphoSitePlus
K4794 Acetylation PhosphoSitePlus
S4822 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S4849 Phosphorylation PhosphoSitePlus   UniProt 23186163
T4852 Phosphorylation PhosphoSitePlus
K4870 Ubiquitination PhosphoSitePlus
S4871 Phosphorylation PhosphoSitePlus
S4883 Phosphorylation PhosphoSitePlus
S4955 Phosphorylation PhosphoSitePlus
R4966 Methylation PhosphoSitePlus
S4974 Phosphorylation PhosphoSitePlus
R4975 Methylation PhosphoSitePlus
R4978 Methylation PhosphoSitePlus
K5024 Methylation PhosphoSitePlus
K5276 Acetylation PhosphoSitePlus
T5297 Phosphorylation PhosphoSitePlus
S5341 Phosphorylation PhosphoSitePlus
T5347 Phosphorylation PhosphoSitePlus
Y5349 Phosphorylation PhosphoSitePlus
S5361 Phosphorylation PhosphoSitePlus
T5374 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K5378 Ubiquitination PhosphoSitePlus
Y5412 Phosphorylation PhosphoSitePlus
S5498 Phosphorylation PhosphoSitePlus
S5499 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation HPRD 18669648
T29 Phosphorylation HPRD 18669648
S31 Phosphorylation HPRD 18669648
S45 Phosphorylation HPRD 18669648
S48 Phosphorylation HPRD 18669648, 18452278
S468 Phosphorylation HPRD 18452278
S609 Phosphorylation HPRD 18452278
S618 Phosphorylation HPRD 18452278
T1195 Phosphorylation HPRD 20068231
S1293 Phosphorylation HPRD 20068231
S1294 Phosphorylation HPRD 20068231
S1298 Phosphorylation HPRD 20068231
S1606 Phosphorylation HPRD 20068231
T1647 Phosphorylation HPRD 20068231
S1671 Phosphorylation HPRD 19651622, 20068231, 18452278
S1820 Phosphorylation HPRD 17525332
S1834 Phosphorylation HPRD 18452278
S1854 Phosphorylation HPRD 18452278
T1865 Phosphorylation HPRD 20068231, 18452278
S2155 Phosphorylation HPRD 19413330, 20068231
T2228 Phosphorylation HPRD 20068231, 18452278
T2240 Phosphorylation HPRD 19651622, 18669648, 20068231
S2274 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995, 20068231
S2295 Phosphorylation HPRD 20068231
S2296 Phosphorylation HPRD 18669648, 18452278
S2298 Phosphorylation HPRD 18669648, 18452278
Y2299 Phosphorylation HPRD 18669648
S2309 Phosphorylation HPRD 18669648, 20068231
S2311 Phosphorylation HPRD 18669648
T2323 Phosphorylation HPRD 18669648
S2640 Phosphorylation HPRD 18767875
S2726 Phosphorylation HPRD 18669648
T2742 Phosphorylation HPRD 20068231
S3130 Phosphorylation HPRD 17081983
T3197 Phosphorylation HPRD 18669648, 20068231
S3199 Phosphorylation HPRD 18669648, 20068231
S3620 Phosphorylation HPRD 20068231
S3624 Phosphorylation HPRD 20068231
S3837 Phosphorylation HPRD 18669648
S4011 Phosphorylation HPRD 20068231
S4215 Phosphorylation HPRD 18669648, 20068231
S4359 Phosphorylation HPRD 20068231, 18452278
S4738 Phosphorylation HPRD 17322306, 18767875, 20058876, ...19664995, 19651622, 18669648, 20068231
S4780 Phosphorylation HPRD 20068231
S4783 Phosphorylation HPRD 20068231
T4787 Phosphorylation HPRD 20068231
S4822 Phosphorylation HPRD 18669648, 19664995
S4849 Phosphorylation HPRD 20068231, 18452278
S5498 Phosphorylation HPRD 20068231
S5499 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S102 R102 Biomuta DOID:3571 / liver cancer [ icgc ]
Y298 * Biomuta DOID:2531 / hematologic cancer [ icgc ]
S654 F654 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1065 L1065 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1263 * Biomuta DOID:2531 / hematologic cancer [ icgc ]
S1298 Y1298 Biomuta DOID:3571 / liver cancer [ icgc ]
S1331 P1331 Biomuta DOID:363 / uterine cancer [ tcga ]
K1610 * Biomuta DOID:2531 / hematologic cancer [ icgc ]
S1671 R1671 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1671 I1671 Biomuta DOID:1324 / lung cancer [ tcga ]
S1872 I1872 Biomuta DOID:363 / uterine cancer [ tcga ]
K1896 N1896 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T1911 S1911 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T2131 P2131 Biomuta DOID:2994 / germ cell cancer [ tcga ]
S2251 L2251 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S2274 L2274 Biomuta DOID:1909 / melanoma [ tcga ]
S2296 Y2296 Biomuta DOID:363 / uterine cancer [ tcga ]
S2309 * Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:1324 / lung cancer [ cosmic, tcga ]
S2311 F2311 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T2323 K2323 Biomuta DOID:3571 / liver cancer [ icgc ]
T2332 I2332 Biomuta DOID:263 / kidney cancer [ cosmic ]
R2471 * Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ icgc ]
S2725 R2725 Biomuta DOID:3571 / liver cancer [ icgc ]
R2774 W2774 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R2860 H2860 Biomuta DOID:10534 / stomach cancer [ tcga ]
R2903 I2903 Biomuta DOID:3070 / malignant glioma [ tcga ]
R2905 C2905 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R2915 * Biomuta DOID:2531 / hematologic cancer [ icgc ]
R2922 Q2922 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
R2922 W2922 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S2969 L2969 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K3119 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S3199 N3199 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R3626 W3626 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R3727 C3727 Biomuta DOID:1909 / melanoma [ cosmic ]
R3727 G3727 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S4359 L4359 Biomuta DOID:1612 / breast cancer [ tcga ]
K4470 N4470 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S4534 R4534 Biomuta DOID:3571 / liver cancer [ icgc ]
S4727 P4727 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K4756 N4756 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K4776 R4776 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K4776 T4776 Biomuta DOID:3070 / malignant glioma [ tcga ]
S4849 G4849 Biomuta DOID:363 / uterine cancer [ tcga ]
S4871 R4871 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S4883 R4883 Biomuta DOID:3571 / liver cancer [ icgc ]
S4955 F4955 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
Y5412 C5412 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]