iPTMnet Report for O14654 (IRS4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14654 / IRS4_HUMAN
Protein Name Insulin receptor substrate 4
Gene Name Name: IRS4
Organism Homo sapiens (Human)

PRO ID PR:O14654
DAG View
PRO Name insulin receptor substrate 4 (human)
Definition An insulin receptor substrate 4 that is encoded in the genome of human.
Short Label hIRS4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14654 (IRS4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
T7 Phosphorylation PhosphoSitePlus
S64 Phosphorylation HPRD   PhosphoSitePlus 18452278
S66 Phosphorylation HPRD   PhosphoSitePlus 18452278
S68 Phosphorylation HPRD   PhosphoSitePlus 18452278
K99 Ubiquitination PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
R384 Methylation PhosphoSitePlus
R398 Methylation PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
R410 Methylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
R442 Methylation PhosphoSitePlus
R444 Methylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
T552 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
T620 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
Y656 Phosphorylation PhosphoSitePlus
R661 Methylation PhosphoSitePlus
K671 Acetylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
R684 Methylation PhosphoSitePlus
Y700 Phosphorylation HPRD   IntAct   PhosphoSitePlus 11316748
S714 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
Y717 Phosphorylation HPRD   IntAct   PhosphoSitePlus 11316748
S728 Phosphorylation PhosphoSitePlus
R741 Methylation PhosphoSitePlus
Y743 Phosphorylation HPRD   IntAct   PhosphoSitePlus 11316748
R749 Methylation PhosphoSitePlus
S751 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
Y779 Phosphorylation HPRD   IntAct   PhosphoSitePlus   RLIMS-P 35550247, 11316748
K803 Ubiquitination PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
Y808 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
Y828 Phosphorylation PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
R839 Methylation PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
Y847 Phosphorylation PhosphoSitePlus
S856 Phosphorylation HPRD   PhosphoSitePlus 19413330
S859 Phosphorylation HPRD   PhosphoSitePlus 19413330
S863 Phosphorylation PhosphoSitePlus
S865 Phosphorylation HPRD   PhosphoSitePlus 19413330
S872 Phosphorylation HPRD   PhosphoSitePlus 19413330
S874 Phosphorylation HPRD   PhosphoSitePlus 19413330
S877 Phosphorylation HPRD   PhosphoSitePlus 19413330
K897 Ubiquitination PhosphoSitePlus
R913 Methylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
Y921 Phosphorylation PhosphoSitePlus   UniProt 15316024
K928 Ubiquitination PhosphoSitePlus
T938 O-Glycosylation GlyGen 30620550
T938 Phosphorylation PhosphoSitePlus
R952 Methylation PhosphoSitePlus
Y1038 Phosphorylation PhosphoSitePlus
Y1046 Phosphorylation HPRD 18083107
S1061 Phosphorylation PhosphoSitePlus
S1091 Phosphorylation PhosphoSitePlus
R1097 Methylation PhosphoSitePlus
S1107 Phosphorylation HPRD   PhosphoSitePlus 19413330
R1176 Methylation PhosphoSitePlus
S1231 Phosphorylation HPRD   PhosphoSitePlus 19413330
T1237 Phosphorylation HPRD   PhosphoSitePlus 19413330
S1252 Phosphorylation PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048054 (hIRS4/PhosTyr+) p PRO