iPTMnet Report for O14647 (CHD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14647 / CHD2_HUMAN
Protein Name Chromodomain-helicase-DNA-binding protein 2
Gene Name Name: CHD2
Organism Homo sapiens (Human)

PRO ID PR:O14647
DAG View
PRO Name chromodomain-helicase-DNA-binding protein 2 (human)
Definition A chromodomain-helicase-DNA-binding protein 2 that is encoded in the genome of human.
Short Label hCHD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14647 (CHD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S75 Phosphorylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231, 24275569
S208 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231, 24275569
T240 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S242 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
T262 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
Y596 Phosphorylation PhosphoSitePlus
T604 Phosphorylation IEDB 31848261
K623 Ubiquitination PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
Y728 Phosphorylation PhosphoSitePlus
Y729 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
Y766 Phosphorylation PhosphoSitePlus
T828 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
T1028 Phosphorylation PhosphoSitePlus
K1062 Ubiquitination PhosphoSitePlus
Y1068 Phosphorylation PhosphoSitePlus
S1075 O-Glycosylation GlyGen 30620550
S1076 O-Glycosylation GlyGen 30620550
T1082 Phosphorylation PhosphoSitePlus
S1085 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1087 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1089 Phosphorylation PhosphoSitePlus
S1091 Phosphorylation PhosphoSitePlus
T1105 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus
T1132 Phosphorylation PhosphoSitePlus
K1141 Ubiquitination PhosphoSitePlus
K1165 Ubiquitination PhosphoSitePlus
T1209 Phosphorylation PhosphoSitePlus
S1213 Phosphorylation PhosphoSitePlus
K1295 Ubiquitination PhosphoSitePlus
K1338 Acetylation PhosphoSitePlus
S1364 Phosphorylation PhosphoSitePlus
S1365 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1369 Phosphorylation PhosphoSitePlus
S1373 Phosphorylation PhosphoSitePlus
S1386 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1429 Phosphorylation PhosphoSitePlus
S1434 Phosphorylation PhosphoSitePlus
S1441 Phosphorylation PhosphoSitePlus
T1448 Phosphorylation PhosphoSitePlus
R1546 Methylation PhosphoSitePlus
S1584 Phosphorylation PhosphoSitePlus
S1590 Phosphorylation PhosphoSitePlus
S1633 Phosphorylation PhosphoSitePlus
R1637 Methylation PhosphoSitePlus
R1685 Methylation PhosphoSitePlus
S1695 Phosphorylation PhosphoSitePlus
Y1715 Phosphorylation PhosphoSitePlus
Y1716 Phosphorylation PhosphoSitePlus
R1718 Methylation PhosphoSitePlus
S1728 Phosphorylation PhosphoSitePlus
Y1736 Phosphorylation PhosphoSitePlus
S1745 Phosphorylation PhosphoSitePlus
Y1753 Phosphorylation PhosphoSitePlus
Y1762 Phosphorylation PhosphoSitePlus
S1785 Phosphorylation PhosphoSitePlus
S1789 Phosphorylation PhosphoSitePlus
S1792 Phosphorylation PhosphoSitePlus
S1795 Phosphorylation PhosphoSitePlus
S1799 Phosphorylation PhosphoSitePlus
S1801 Phosphorylation PhosphoSitePlus
S1807 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1821 Phosphorylation PhosphoSitePlus
T1828 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T164 Phosphorylation HPRD 18691976
S207 Phosphorylation HPRD 19651622, 20068231
S208 Phosphorylation HPRD 19651622, 20068231
T240 Phosphorylation HPRD 18691976, 18669648, 18452278
S242 Phosphorylation HPRD 18691976, 18669648, 18452278
S747 Phosphorylation HPRD 18691976
S1012 Phosphorylation HPRD 18691976
S1364 Phosphorylation HPRD 18691976
S1386 Phosphorylation HPRD 18452278
S1441 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
T164 Phosphorylation HPRD 18691976
S207 Phosphorylation HPRD 19651622, 20068231
S208 Phosphorylation HPRD 19651622, 20068231
T240 Phosphorylation HPRD 18691976, 18669648, 18452278
S242 Phosphorylation HPRD 18691976, 18669648, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S156 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S168 I168 Biomuta DOID:3571 / liver cancer [ cosmic ]
S402 C402 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S402 I402 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K436 T436 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T604 I604 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S708 F708 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S747 I747 Biomuta DOID:3571 / liver cancer [ cosmic ]
T828 P828 Biomuta DOID:1612 / breast cancer [ cosmic ]
S840 F840 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1085 G1085 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S1085 I1085 Biomuta DOID:363 / uterine cancer [ icgc ]
S1091 Y1091 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T1105 M1105 Biomuta DOID:1319 / brain cancer [ cosmic ]
K1165 R1165 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1364 L1364 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S1441 F1441 Biomuta DOID:363 / uterine cancer [ icgc ]
R1546 Q1546 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R1546 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1590 F1590 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1590 C1590 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1637 Q1637 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1685 L1685 Biomuta DOID:3571 / liver cancer [ cosmic ]
R1685 H1685 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1695 Y1695 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1745 F1745 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1792 C1792 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1795 F1795 Biomuta DOID:1612 / breast cancer [ cosmic ]