Protein Information

Cytoscape View


UniProt AC / UniProt ID O14641 / DVL2_HUMAN
Protein Name Segment polarity protein dishevelled homolog DVL-2
Gene Name Name: DVL2
Organism Homo sapiens (Human)

PRO ID PR:O14641
DAG View
PRO Name segment polarity protein dishevelled homolog DVL-2 (human)
Definition A segment polarity protein dishevelled homolog DVL-2 that is encoded in the genome of human.
Short Label hDVL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14641 (DVL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
T14 Phosphorylation PhosphoSitePlus
Y18 Phosphorylation P12931 (SRC) PhosphoSitePlus 19920076
Y27 Phosphorylation P12931 (SRC) PhosphoSitePlus 19920076
K30 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S143 Phosphorylation P49674 (CSNK1E) , P48730 (CSNK1D) PhosphoSitePlus   RLIMS-P   Signor 29426949, 22609948
T151 Phosphorylation PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S194 Phosphorylation RLIMS-P 29426949
S195 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
T206 Phosphorylation P53350 (PLK1) , PR:P53350 (hPLK1) PRO   PhosphoSitePlus   RLIMS-P   Signor 20823832
S211 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19690332, 20068231
S221 Phosphorylation PhosphoSitePlus
S222 Phosphorylation HPRD   PhosphoSitePlus 20068231
T224 Phosphorylation P48730 (CSNK1D) , P49674 (CSNK1E) PhosphoSitePlus   RLIMS-P   Signor 22609948
S227 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S228 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S230 Phosphorylation HPRD 20068231
T250 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation P12931 (SRC) PhosphoSitePlus 19920076
S286 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation P12931 (SRC) PhosphoSitePlus 19920076
K301 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
T364 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
Y463 Phosphorylation P12931 (SRC) PhosphoSitePlus 19920076
K477 Ubiquitination PhosphoSitePlus
Y478 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S562 Phosphorylation RLIMS-P 29426949
S591 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
S618 Phosphorylation RLIMS-P 29426949
S626 Phosphorylation PhosphoSitePlus
R627 Methylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
R633 Methylation PhosphoSitePlus
R649 Methylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
R659 Methylation PhosphoSitePlus
T715 Phosphorylation PhosphoSitePlus
S717 Phosphorylation RLIMS-P 29426949
S720 Phosphorylation PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035549 (hDVL2/Phos:1) pT206 PR:P53350 (hPLK1) PRO 20823832
PR:000047225 (hDVL2/PhosRes+) p PRO
PR:000047226 (hDVL2/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14641 (DVL2) S143 P53350 (PLK1) unknown eFIP 22609948


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O14641 (hDVL2) Interaction PR:P33981 (hTTK) PRO 20823832
PR:O14641 (hDVL2) Interaction PR:P53350 (hPLK1) PRO 20823832
PR:O14641 (hDVL2) Interaction PR:P25054 (hAPC) PRO 20823832
PR:P25054 (hAPC) Interaction PR:O14641 (hDVL2) PRO 20823832
PR:P53350 (hPLK1) Interaction PR:O14641 (hDVL2) PRO 20823832


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y18 * Biomuta DOID:3571 / liver cancer [ icgc ]
T39 N39 Biomuta DOID:3571 / liver cancer [ icgc ]
S155 L155 Biomuta DOID:1909 / melanoma [ cosmic ]
S196 C196 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S211 L211 Biomuta DOID:363 / uterine cancer [ tcga ]
T224 K224 Biomuta DOID:3571 / liver cancer [ icgc ]
S562 N562 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K615 T615 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S630 N630 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R659 * Biomuta DOID:10534 / stomach cancer [ tcga ]
S729 C729 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]