iPTMnet Report O14578 CIT

Protein Information

UniProt AC / UniProt ID	O14578 / CTRO_HUMAN
Protein Name	Citron Rho-interacting kinase
Gene Name	Name: CIT Synonyms:CRIK,KIAA0949,STK21;
Organism	Homo sapiens (Human)

PRO ID	PR:O14578 DAG View
PRO Name	citron Rho-interacting kinase (human)
Definition	A citron Rho-interacting kinase that is encoded in the genome of human.
Short Label	hCIT
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O14578 (CIT) as Substrate

Expanded View

Site	PTM Type	Score	Source	PMID
M1	Acetylation	score1	UniProt	22814378
S44	Phosphorylation	score1	PhosphoSitePlus
K71	Ubiquitination	score1	PhosphoSitePlus
K79	Ubiquitination	score1	PhosphoSitePlus
K95	Ubiquitination	score1	PhosphoSitePlus
K117	Acetylation	score1	PhosphoSitePlus
K126	Ubiquitination	score1	PhosphoSitePlus
T232	Phosphorylation	score1	PhosphoSitePlus
K236	Ubiquitination	score1	PhosphoSitePlus
K245	Ubiquitination	score1	PhosphoSitePlus
K250	Ubiquitination	score1	PhosphoSitePlus
T307	Phosphorylation	score1	PhosphoSitePlus
S308	Phosphorylation	score1	PhosphoSitePlus
K323	Ubiquitination	score1	PhosphoSitePlus
K350	Ubiquitination	score1	PhosphoSitePlus
K362	Acetylation	score1	PhosphoSitePlus
S371	Phosphorylation	score1	PhosphoSitePlus
K380	Ubiquitination	score1	PhosphoSitePlus
S431	Phosphorylation	score1	PhosphoSitePlus
S433	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163, 19690332
S436	Phosphorylation	score1	PhosphoSitePlus
S440	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 16565220, ...18669648, 19690332, 20068231
K467	Ubiquitination	score1	PhosphoSitePlus
S480	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
K489	Ubiquitination	score1	PhosphoSitePlus
K518	Ubiquitination	score1	PhosphoSitePlus
S529	Phosphorylation	score1	PhosphoSitePlus
K553	Ubiquitination	score1	PhosphoSitePlus
S582	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
K600	Ubiquitination	score1	PhosphoSitePlus
S652	Phosphorylation	score1	PhosphoSitePlus
T653	Phosphorylation	score1	PhosphoSitePlus
T656	Phosphorylation	score1	PhosphoSitePlus
T741	Phosphorylation	score1	PhosphoSitePlus
S772	Phosphorylation	score1	PhosphoSitePlus
S794	Phosphorylation	score1	PhosphoSitePlus
K825	Ubiquitination	score1	PhosphoSitePlus
S841	Phosphorylation	score1	PhosphoSitePlus
S846	Phosphorylation	score1	PhosphoSitePlus
S902	Phosphorylation	score1	PhosphoSitePlus
Y969	Phosphorylation	score1	PhosphoSitePlus
S1137	Phosphorylation	score1	PhosphoSitePlus
K1141	Ubiquitination	score1	PhosphoSitePlus
K1158	Ubiquitination	score1	PhosphoSitePlus
K1167	Ubiquitination	score1	PhosphoSitePlus
K1209	Ubiquitination	score1	PhosphoSitePlus
K1229	Ubiquitination	score1	PhosphoSitePlus
K1262	Ubiquitination	score1	PhosphoSitePlus
T1299	Phosphorylation	score1	PhosphoSitePlus
S1305	Phosphorylation	score1	PhosphoSitePlus
T1306	Phosphorylation	score1	PhosphoSitePlus
T1309	Phosphorylation	score1	PhosphoSitePlus
S1322	Phosphorylation	score1	PhosphoSitePlus
S1343	Phosphorylation	score1	PhosphoSitePlus
S1344	Phosphorylation	score1	PhosphoSitePlus
T1345	Phosphorylation	score1	PhosphoSitePlus
S1350	Phosphorylation	score1	PhosphoSitePlus
T1382	Phosphorylation	score1	PhosphoSitePlus
T1410	Phosphorylation	score1	PhosphoSitePlus
Y1417	Phosphorylation	score1	PhosphoSitePlus
T1419	Phosphorylation	score1	PhosphoSitePlus
S1432	Phosphorylation	score1	PhosphoSitePlus
Y1467	Phosphorylation	score1	PhosphoSitePlus
S1473	Phosphorylation	score1	PhosphoSitePlus
K1571	Ubiquitination	score1	PhosphoSitePlus
S1582	Phosphorylation	score1	PhosphoSitePlus
K1721	Acetylation	score2	PhosphoSitePlus UniProt	19608861
Y1759	Phosphorylation	score1	PhosphoSitePlus
T1760	Phosphorylation	score1	PhosphoSitePlus
S1826	Phosphorylation	score1	IEDB	35494241
Y1929	Phosphorylation	score1	PhosphoSitePlus
T1934	Phosphorylation	score1	PhosphoSitePlus
S1939	Phosphorylation	score1	PhosphoSitePlus
S1940	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S1948	Phosphorylation	score1	PhosphoSitePlus
S1954	Phosphorylation	score1	PhosphoSitePlus
T1955	Phosphorylation	score1	PhosphoSitePlus
S1971	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17081983
S1981	Phosphorylation	score2	IEDB PhosphoSitePlus	27920218
S1987	Phosphorylation	score1	PhosphoSitePlus
T1988	Phosphorylation	score1	PhosphoSitePlus
S1993	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 17081983
S2001	Phosphorylation	score1	PhosphoSitePlus
S2002	Phosphorylation	score1	PhosphoSitePlus
R2003	Methylation	score1	PhosphoSitePlus
T2013	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S2025	Phosphorylation	score1	PhosphoSitePlus
S2026	Phosphorylation	score1	PhosphoSitePlus

Site	PTM Type	Score	Source	PMID
T307	Phosphorylation	score0	HPRD	19691289
S433	Phosphorylation	score0	HPRD	19691289
S440	Phosphorylation	score0	HPRD	19413330, 18691976, 20058876, ...19664994, 19007248, 16565220, 19664995, 18669648, 20068231, 19691289
S652	Phosphorylation	score0	HPRD	18452278
T653	Phosphorylation	score0	HPRD	18452278
T656	Phosphorylation	score0	HPRD	18452278
S1322	Phosphorylation	score0	HPRD	19691289
S1343	Phosphorylation	score0	HPRD	19691289
T1345	Phosphorylation	score0	HPRD	19691289
S1432	Phosphorylation	score0	HPRD	20068231
S1939	Phosphorylation	score0	HPRD	19691289
S1940	Phosphorylation	score0	HPRD	20068231
S1971	Phosphorylation	score0	HPRD	17081983, 20068231
S1987	Phosphorylation	score0	HPRD	18691976
S1993	Phosphorylation	score0	HPRD	17081983, 20068231, 18452278

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K771	Ubiquitination		score1	PhosphoSitePlus
	S1437	Phosphorylation		score1	PhosphoSitePlus

Site	PTM Type	Score	Source
S480	Phosphorylation	score1	PhosphoSitePlus
S699	Phosphorylation	score1	PhosphoSitePlus
T709	Phosphorylation	score1	PhosphoSitePlus

O14578 (CIT) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P24844 (MYL9)	T19	score3	PhosphoSitePlus	12802051, 18854160
	P24844 (MYL9)	S20	score2	PhosphoSitePlus	12802051

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S44	C44	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K95	N95	Biomuta	DOID:363 / uterine cancer [ icgc ]
K117	T117	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K250	N250	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ icgc ]
K323	Q323	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K380	N380	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K467	N467	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S529	F529	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
T653	S653	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S841	I841	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S841	R841	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S1137	N1137	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K1158	N1158	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1209	R1209	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S1344	L1344	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S1344	*	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S1432	F1432	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T1760	M1760	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ]
Y1929	H1929	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S1948	I1948	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T1988	M1988	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O14578 (CIT)

Protein Information

Interactive Sequence View

O14578 (CIT) as Substrate

O14578 (CIT) as PTM Enzyme

PTM sites affected in variants