iPTMnet Report for O14545 (TRAFD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14545 / TRAD1_HUMAN
Protein Name TRAF-type zinc finger domain-containing protein 1
Gene Name Name: TRAFD1
Synonyms:FLN29;
Organism Homo sapiens (Human)

PRO ID PR:O14545
DAG View
PRO Name TRAF-type zinc finger domain-containing protein 1 (human)
Definition A TRAF-type zinc finger domain-containing protein 1 that is encoded in the genome of human.
Short Label hTRAFD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14545 (TRAFD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
C32 Methylation IEDB 31844290
K43 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
C93 Methylation IEDB 31844290
S98 Phosphorylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
C109 Methylation IEDB 31844290
K126 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus   UniProt 23186163
S209 Phosphorylation PhosphoSitePlus
C267 Methylation IEDB 31844290
S272 Phosphorylation PhosphoSitePlus
S278 O-Glycosylation GlyGen 30379171, 29351928
S278 Phosphorylation PhosphoSitePlus   UniProt 23186163
S320 Phosphorylation PhosphoSitePlus   UniProt 24275569
T323 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S326 O-Glycosylation GlyGen 30379171, 29351928
S326 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S327 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 24275569, 20068231, 17081983
S409 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T414 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S415 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 24275569, 17287340, 19690332, 20068231, 17081983
S430 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y433 Phosphorylation PhosphoSitePlus
S470 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S479 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S501 Phosphorylation IEDB   PhosphoSitePlus 35494241
S530 Phosphorylation phospho.ELM 18669648
Y537 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
T552 Phosphorylation PhosphoSitePlus
Y558 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S320 Phosphorylation HPRD 18212344
T323 Phosphorylation HPRD 17081983, 19691289, 19664995, ...19651622, 19415658, 20068231
S325 Phosphorylation HPRD 19651622, 18691976, 20058876, ...19415658, 19664995
S326 Phosphorylation HPRD 18691976, 18669648, 19664995, ...20068231
S327 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20058876, 15302935, 19664995, 19691289, 19651622, 19664994, 18669648, 18767875, 19415658, 20068231, 18212344
S409 Phosphorylation HPRD 20068231
T414 Phosphorylation HPRD 18691976, 17081983, 20230923, ...20058876, 19664995, 19691289, 19651622, 18669648, 20068231
S415 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 18212344, 19691289, 20230923, 16964243, 18767875, 15302935, 19007248, 18452278, 19651622, 19664994, 18669648, 19664995, 16565220, 19415658, 20068231, 20058876
S470 Phosphorylation HPRD 18669648
S530 Phosphorylation HPRD 18669648
S534 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S98 F98 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K103 N103 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S326 F326 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S327 C327 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]