iPTMnet Report for O14544 (SOCS6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14544 / SOCS6_HUMAN
Protein Name Suppressor of cytokine signaling 6
Gene Name Name: SOCS6
Synonyms:CIS4,SOCS4;
Organism Homo sapiens (Human)

PRO ID PR:O14544
DAG View
PRO Name suppressor of cytokine signaling 6 (human)
Definition A suppressor of cytokine signaling 6 that is encoded in the genome of human.
Short Label hSOCS6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14544 (SOCS6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
Y502 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 Y12 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K173 T173 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S327 T327 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S405 Y405 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S405 F405 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]