iPTMnet Report for O14543 (SOCS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14543 / SOCS3_HUMAN
Protein Name Suppressor of cytokine signaling 3
Gene Name Name: SOCS3
Synonyms:CIS3,SSI3;
Organism Homo sapiens (Human)

PRO ID PR:O14543
DAG View
PRO Name suppressor of cytokine signaling 3 (human)
Definition A suppressor of cytokine signaling 3 that is encoded in the genome of human.
Short Label hSOCS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14543 (SOCS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
S13 O-Glycosylation GlyGen 30379171
K23 Ubiquitination PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
Y204 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 12783885
Y204 Phosphorylation O60674 (JAK2) PhosphoSitePlus 12783885
Y204 Phosphorylation P06239 (LCK) phospho.ELM   PhosphoSitePlus 12783885
K206 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P 12783885, 11331873, 15173187
Y221 Phosphorylation O60674 (JAK2) PhosphoSitePlus 12783885
Y221 Phosphorylation P06239 (LCK) phospho.ELM   PhosphoSitePlus 12783885, 15173187


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 N13 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]