iPTMnet Report for O14530 (TXNDC9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14530 / TXND9_HUMAN
Protein Name Thioredoxin domain-containing protein 9
Gene Name Name: TXNDC9
Synonyms:APACD;
Organism Homo sapiens (Human)

PRO ID PR:O14530
DAG View
PRO Name thioredoxin domain-containing protein 9 (human)
Definition A thioredoxin domain-containing protein 9 that is encoded in the genome of human.
Short Label hTXNDC9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14530 (TXNDC9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K23 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
C94 Methylation IEDB 31844290
K116 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S188 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
K201 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus   UniProt 21406692
S223 Phosphorylation PhosphoSitePlus   UniProt 21406692
Site PTM Type PTM Enzyme Score Source PMID
Y187 Phosphorylation HPRD 20068231
S188 Phosphorylation HPRD 18669648, 20068231
S221 Phosphorylation HPRD 19651622
S223 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K62 I62 Biomuta DOID:363 / uterine cancer [ icgc ]
K87 N87 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C94 S94 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K130 E130 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S221 L221 Biomuta DOID:4159 / skin cancer [ cosmic ]
S223 F223 Biomuta DOID:9256 / colorectal cancer [ cosmic ]