Protein Information

Cytoscape View

UniProt AC / UniProt ID O14529 / CUX2_HUMAN
Protein Name Homeobox protein cut-like 2
Gene Name Name: CUX2
Organism Homo sapiens (Human)

PRO ID PR:O14529
DAG View
PRO Name homeobox protein cut-like 2 (human)
Definition A homeobox protein cut-like 2 that is encoded in the genome of human.
Short Label hCUX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O14529 (CUX2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation HPRD 20068231
S143 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
T151 Phosphorylation HPRD 20068231
S152 Phosphorylation HPRD   PhosphoSitePlus 20068231
T157 Phosphorylation HPRD   PhosphoSitePlus 20068231
T159 Phosphorylation HPRD   PhosphoSitePlus 18669648
S162 Phosphorylation HPRD   PhosphoSitePlus 18669648
K351 Acetylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K596 Acetylation PhosphoSitePlus
S635 Phosphorylation HPRD   PhosphoSitePlus 20068231
T637 Phosphorylation PhosphoSitePlus
T642 Phosphorylation HPRD   PhosphoSitePlus 20068231
T645 Phosphorylation HPRD 20068231
S647 Phosphorylation HPRD 20068231
T672 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S927 Phosphorylation PhosphoSitePlus
K943 Ubiquitination PhosphoSitePlus
T992 Phosphorylation PhosphoSitePlus
K1118 Methylation PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
Y1470 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T151 M151 Biomuta DOID:363 / uterine cancer [ tcga ]
T151 K151 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T151 S151 Biomuta DOID:1324 / lung cancer [ tcga ]
S152 L152 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:10534 / stomach cancer [ cosmic ]
T157 M157 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y362 C362 Biomuta DOID:1909 / melanoma [ cosmic ]
K568 I568 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K596 R596 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T642 M642 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T645 A645 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T992 P992 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]