iPTMnet Report for O14511 (NRG2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14511 / NRG2_HUMAN
Protein Name Pro-neuregulin-2, membrane-bound isoform precursor
Gene Name Name: NRG2
Synonyms:NTAK;
Organism Homo sapiens (Human)

PRO ID PR:O14511
DAG View
PRO Name pro-neuregulin-2, membrane-bound isoform (human)
Definition A pro-neuregulin-2, membrane-bound isoform that is encoded in the genome of human.
Short Label hNRG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14511 (NRG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
T333 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T334 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S549 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
R837 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S549 R549 Biomuta DOID:363 / uterine cancer [ icgc ]
S579 F579 Biomuta DOID:4159 / skin cancer [ cosmic ]