Protein Information

Cytoscape View

UniProt AC / UniProt ID O14492 / SH2B2_HUMAN
Protein Name SH2B adapter protein 2
Gene Name Name: SH2B2
Organism Homo sapiens (Human)

PRO ID PR:O14492
DAG View
PRO Name SH2B adapter protein 2 (human)
Definition An SH2B adapter protein 2 that is encoded in the genome of human.
Short Label hSH2B2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O14492 (SH2B2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K108 Ubiquitination PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S598 Phosphorylation P31749 (AKT1) neXtProt 16141217
Y629 Phosphorylation IntAct   PRO   PhosphoSitePlus   UniProt 15737992, 9233773
Site PTM Type PTM Enzyme Score Source PMID
S641 Phosphorylation P31749 (AKT1) HPRD 16141217


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049227 (hSH2B2/Phos:1) pY629 PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14492 (SH2B2) Y629 P22681 (CBL) unknown eFIP 15737992
Phosphorylation O60674 (JAK2) Y813 O14492 (SH2B2) unknown eFIP 15767667
Phosphorylation P04626 (ERBB2) Y1222 O14492 (SH2B2) unknown eFIP 16273093
Phosphorylation P09619 (PDGFRB) Y1021 O14492 (SH2B2) unknown eFIP 9989826