iPTMnet Report for O08586 (Pten)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O08586 / PTEN_MOUSE
Protein Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Gene Name Name: Pten
Synonyms:Mmac1;
Organism Mus musculus (Mouse)

PRO ID PR:O08586
DAG View
PRO Name phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (mouse)
Definition A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN that is encoded in the genome of mouse.
Short Label mPTEN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O08586 (Pten) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y46 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus   UniProt 21183079
T366 Phosphorylation Q9WV60 (Gsk3b) , Q60806 (Plk3) PhosphoSitePlus   UniProt 20940307
S370 Phosphorylation Q60737 (Csnk2a1) , Q60806 (Plk3) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 20940307, 24569712, 17242355
S380 Phosphorylation P70335 (Rock1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22759359, 19403525, 14522959, ...24882728, 24569712, 27221467, 26222260, 17975737, 20008297, 17875968, 25594415
T382 Phosphorylation P70335 (Rock1) PhosphoSitePlus   RLIMS-P   UniProt 22759359, 19403525, 24569712, ...27221467, 20008297, 17875968
T383 Phosphorylation P70335 (Rock1) PhosphoSitePlus   RLIMS-P   UniProt 22759359, 19403525, 24569712, ...27221467, 20008297, 17875968
S385 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17242355, 24569712, 21183079