iPTMnet Report for O00767 (SCD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00767 / SCD_HUMAN
Protein Name Stearoyl-CoA desaturase
Gene Name Name: SCD
Synonyms:FADS5;
Organism Homo sapiens (Human)

PRO ID PR:O00767
DAG View
PRO Name stearoyl-CoA desaturase (human)
Definition A stearoyl-CoA desaturase that is encoded in the genome of human.
Short Label hSCD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00767 (SCD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y14 Phosphorylation PhosphoSitePlus   RLIMS-P 28724430
K34 Ubiquitination PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus   RLIMS-P 28724430
K51 Sumoylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus   RLIMS-P 28724430
Y59 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
C96 Methylation IEDB 31844290
K162 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S198 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18578522, 23186163, ...19651622, 18669648
T199 Phosphorylation HPRD   PhosphoSitePlus 18691976
S203 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
K209 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
C326 Methylation IEDB 31844290
K338 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
T351 Phosphorylation HPRD   PhosphoSitePlus 19651622
K357 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K51 Q51 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K68 T68 Biomuta DOID:3571 / liver cancer [ cosmic ]
C96 F96 Biomuta DOID:3571 / liver cancer [ cosmic ]
T199 A199 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T199 M199 Biomuta DOID:363 / uterine cancer [ icgc ]
K278 N278 Biomuta DOID:1324 / lung cancer [ cosmic ]