iPTMnet Report for O00754 (MAN2B1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00754 / MA2B1_HUMAN
Protein Name Lysosomal alpha-mannosidase precursor
Gene Name Name: MAN2B1
Synonyms:LAMAN,MANB;
Organism Homo sapiens (Human)

PRO ID PR:O00754
DAG View
PRO Name lysosomal alpha-mannosidase (human)
Definition A lysosomal alpha-mannosidase that is encoded in the genome of human.
Short Label hMAN2B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00754 (MAN2B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y118 Phosphorylation PhosphoSitePlus
N133 N-Glycosylation GlyGen 23090970, 24190977
Y295 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
N310 N-Glycosylation GlyGen 24190977
K334 Ubiquitination PhosphoSitePlus
N367 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
S450 Phosphorylation PhosphoSitePlus
N497 N-Glycosylation GlyGen 23345538
N645 N-Glycosylation GlyGen 24190977
N692 N-Glycosylation GlyGen 23090970, 29741879, 24190977
Y704 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
N766 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
N774 N-Glycosylation GlyGen 24190977
N832 N-Glycosylation GlyGen 29741879, 24190977
T904 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
N930 N-Glycosylation GlyGen   UniProt 29741879, 12754519, 24190977
T936 Phosphorylation PhosphoSitePlus
T954 Phosphorylation PhosphoSitePlus
T955 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S346 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T301 N301 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y704 * Biomuta DOID:3571 / liver cancer [ icgc ]
S715 L715 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S731 R731 Biomuta DOID:1793 / pancreatic cancer [ tcga ]