iPTMnet Report for O00754 (MAN2B1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00754 / MA2B1_HUMAN
Protein Name Lysosomal alpha-mannosidase precursor
Gene Name Name: MAN2B1
Synonyms:LAMAN,MANB;
Organism Homo sapiens (Human)

PRO ID PR:O00754
DAG View
PRO Name lysosomal alpha-mannosidase (human)
Definition A lysosomal alpha-mannosidase that is encoded in the genome of human.
Short Label hMAN2B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00754 (MAN2B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C11 Methylation IEDB 31844290
Y118 Phosphorylation PhosphoSitePlus
N133 N-Glycosylation GlyGen 23090970, 34089345, 24190977
Y295 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
N310 N-Glycosylation GlyGen 24190977
K334 Ubiquitination PhosphoSitePlus
N367 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 24190977, ...19159218, 34089345
S371 O-Glycosylation GlyGen 22661428
S450 Phosphorylation PhosphoSitePlus
N497 N-Glycosylation GlyGen 23345538
N645 N-Glycosylation GlyGen 24190977
N651 N-Glycosylation GlyGen 34089345
N692 N-Glycosylation GlyGen 23090970, 29741879, 24190977, ...34089345
Y704 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
N766 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 24190977, ...19159218, 34089345
N774 N-Glycosylation GlyGen 24190977
N832 N-Glycosylation GlyGen 29741879, 24190977
T904 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
N930 N-Glycosylation GlyGen   UniProt 29741879, 12754519, 24190977
S932 O-Glycosylation GlyGen 34019948, 22661428, 35289036, ...35254053
T936 Phosphorylation PhosphoSitePlus
T954 Phosphorylation PhosphoSitePlus
T955 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N497 N-Glycosylation PRO 23345538
Site PTM Type PTM Enzyme Score Source PMID
S346 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N133 D133 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T301 N301 Biomuta DOID:3571 / liver cancer [ cosmic ]
S347 N347 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S715 L715 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S731 R731 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S932 R932 Biomuta DOID:1324 / lung cancer [ cosmic ]