iPTMnet Report for O00716 (E2F3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00716 / E2F3_HUMAN
Protein Name Transcription factor E2F3
Gene Name Name: E2F3
Synonyms:KIAA0075;
Organism Homo sapiens (Human)

PRO ID PR:O00716
DAG View
PRO Name transcription factor E2F3 (human)
Definition A transcription factor E2F3 that is encoded in the genome of human.
Short Label hE2F3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00716 (E2F3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
R121 Methylation PhosphoSitePlus
S124 Phosphorylation O14757 (CHEK1) , O96017 (CHEK2) PhosphoSitePlus   RLIMS-P   Signor 19917728, 26921499
T152 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
Y179 Phosphorylation phospho.ELM 18669648
S182 Phosphorylation phospho.ELM 18669648
K188 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K168 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885
K171 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885
K176 Acetylation PR:000027108 (h(CBP-p300)) PRO 10753885


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047233 (hE2F3/PhosRes+) p PRO
PR:000028778 (hE2F3/iso:1/Ac:1) acK168,acK171,acK176 PR:000027108 (h(CBP-p300)) PRO 10753885


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T152 A152 Biomuta DOID:4159 / skin cancer [ cosmic ]
T152 N152 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S172 C172 Biomuta DOID:1612 / breast cancer [ cosmic ]
K176 N176 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y179 C179 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y349 F349 Biomuta DOID:5158 / pleural cancer [ cosmic ]