iPTMnet Report for O00592 (PODXL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00592 / PODXL_HUMAN
Protein Name Podocalyxin precursor
Gene Name Name: PODXL
Synonyms:PCLP,PCLP1;
Organism Homo sapiens (Human)

PRO ID PR:O00592
DAG View
PRO Name podocalyxin (human)
Definition A podocalyxin-like protein 1 that is encoded in the genome of human.
Short Label hPODXL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00592 (PODXL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T60 Phosphorylation PhosphoSitePlus
S77 O-Glycosylation GlyGen 25813380
T81 O-Glycosylation GlyGen 25813380
T82 O-Glycosylation GlyGen 25813380
N104 N-Glycosylation GlyGen 29741879
T117 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T118 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T119 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S122 Phosphorylation PhosphoSitePlus
S125 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T126 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S128 Phosphorylation PhosphoSitePlus
S162 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S163 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T167 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T168 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T171 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S172 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T173 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T179 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T180 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T184 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S185 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S185 Phosphorylation PhosphoSitePlus
S188 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S188 Phosphorylation PhosphoSitePlus
T193 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T193 Phosphorylation PhosphoSitePlus
S194 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S194 Phosphorylation PhosphoSitePlus
T195 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T195 Phosphorylation PhosphoSitePlus
T200 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T202 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S203 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S204 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T232 O-Glycosylation GlyGen 30459171
T238 O-Glycosylation GlyGen 25813380
S244 O-Glycosylation GlyGen 25813380
T252 O-Glycosylation GlyGen 25813380
S253 O-Glycosylation GlyGen 25813380
T258 O-Glycosylation GlyGen 25813380
S261 O-Glycosylation GlyGen 30459171
T267 O-Glycosylation GlyGen 30459171
S269 O-Glycosylation GlyGen 30459171
T295 O-Glycosylation GlyGen 25813380
T299 O-Glycosylation GlyGen 25813380
S300 O-Glycosylation GlyGen 25813380
T303 O-Glycosylation GlyGen 25813380
T307 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T309 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S315 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S315 Phosphorylation PhosphoSitePlus
S316 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S317 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S317 Phosphorylation PhosphoSitePlus
T319 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S322 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T323 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T324 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T330 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S332 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 32574038, 25813380
T334 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380, ...32574038
S339 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S339 Phosphorylation PhosphoSitePlus
N360 N-Glycosylation GlyGen 29741879, 24190977
N364 N-Glycosylation GlyGen 24190977
T387 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S401 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S405 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T407 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T414 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T417 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K422 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus   UniProt 21406692
S537 Phosphorylation PhosphoSitePlus   UniProt 20068231
K547 Ubiquitination PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus   UniProt 21406692
Site PTM Type PTM Enzyme Score Source PMID
T299 Phosphorylation HPRD 20068231
S519 Phosphorylation HPRD 18669648, 20068231, 18452278
S529 Phosphorylation HPRD 20068231
S537 Phosphorylation HPRD 19664994, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T267 Phosphorylation HPRD 20068231
S487 Phosphorylation HPRD 18669648, 20068231, 18452278
S497 Phosphorylation HPRD 20068231
S505 Phosphorylation HPRD 19664994, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S77 L77 Biomuta DOID:363 / uterine cancer [ icgc ]
T82 A82 Biomuta DOID:363 / uterine cancer [ icgc ]
T82 P82 Biomuta DOID:1612 / breast cancer [ cosmic ]
N104 S104 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T126 P126 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T126 A126 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T167 I167 Biomuta DOID:363 / uterine cancer [ icgc ]
T171 I171 Biomuta DOID:363 / uterine cancer [ cosmic ]
S172 F172 Biomuta DOID:1324 / lung cancer [ cosmic ]
T173 S173 Biomuta DOID:1324 / lung cancer [ cosmic ]
T179 M179 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S194 L194 Biomuta DOID:1324 / lung cancer [ icgc ]
T195 M195 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S244 G244 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T267 M267 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T295 I295 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T299 M299 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T303 M303 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S316 C316 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S317 N317 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S322 L322 Biomuta [ cosmic ]
T330 P330 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S520 A520 Biomuta DOID:4159 / skin cancer [ cosmic ]
K547 N547 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]