iPTMnet Report for O00571 (DDX3X)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00571 / DDX3X_HUMAN
Protein Name ATP-dependent RNA helicase DDX3X
Gene Name Name: DDX3X
Synonyms:DBX;
Organism Homo sapiens (Human)

PRO ID PR:O00571
DAG View
PRO Name ATP-dependent RNA helicase DDX3X (human)
Definition An ATP-dependent RNA helicase DDX3X that is encoded in the genome of human.
Short Label hDDX3X
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00571 (DDX3X) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895, 10859333, 20068231
S24 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K66 Methylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 16094384
S70 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S74 Phosphorylation phospho.ELM   PhosphoSitePlus 14729942, 17287340
R75 Methylation PhosphoSitePlus
S76 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S78 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
R79 Methylation PhosphoSitePlus
K81 Methylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus   UniProt 23186163
S83 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus   UniProt 23186163
R88 Methylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus   UniProt 23186163
S92 Phosphorylation PhosphoSitePlus
R93 Methylation PhosphoSitePlus
R95 Methylation PhosphoSitePlus
R99 Methylation PhosphoSitePlus
R101 Methylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23478265
S102 Phosphorylation Q14164 (IKBKE) PhosphoSitePlus 23478265
Y104 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S109 Phosphorylation PhosphoSitePlus
R110 Methylation PhosphoSitePlus
S114 O-Glycosylation GlyGen 33214551, 28510447, 32870666, ...30397120, 34725712, 26853435, 30444036, 29351928, 34019948, 35083852, 31492838, 32119511, 35254053, 33465208
S114 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus   UniProt 19608861
K118 Methylation PhosphoSitePlus
K118 Sumoylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
R121 Methylation PhosphoSitePlus
S125 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K130 Acetylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus   UniProt 21406692
K138 Methylation PhosphoSitePlus
K138 Sumoylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
S181 Phosphorylation UniProt 18583960
S183 Phosphorylation PhosphoSitePlus   UniProt 24275569, 18583960
Y200 Phosphorylation PhosphoSitePlus
T204 O-Glycosylation GlyGen 33214551, 28510447, 32870666, ...30397120, 34725712, 26853435, 30444036, 29351928, 34019948, 35083852, 31492838, 32119511, 35254053, 33465208
T204 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16280325, 17379183
T204 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 17379183, 16280325
T204 Phosphorylation P24941 (CDK2) PhosphoSitePlus 16280325
K208 Ubiquitination PhosphoSitePlus
K215 Sumoylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
S240 Phosphorylation UniProt 18583960
Y243 Phosphorylation PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
S269 Phosphorylation UniProt 18583960
Y283 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
R315 Methylation PhosphoSitePlus
C317 Methylation IEDB 31844290
C317 S-Nitrosylation dbSNO 2212679, 22126794
T323 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 16280325, 17379183
T323 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 16280325, 17379183
K335 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
Y343 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
R362 Methylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18583960, 29222110
T438 Phosphorylation PhosphoSitePlus   UniProt 18583960
S442 Phosphorylation UniProt 18583960
K452 Ubiquitination PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus   UniProt 18583960
Y462 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
C468 Methylation IEDB 31844290
T469 Phosphorylation UniProt 29222110
S470 Phosphorylation UniProt 29222110
R475 Methylation PhosphoSitePlus
R478 Methylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus   UniProt 18583960
T542 Phosphorylation UniProt 18583960
S543 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18583960, 29222110
K554 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
Y576 Phosphorylation PhosphoSitePlus
Y580 Phosphorylation PhosphoSitePlus
K581 Methylation PhosphoSitePlus
S584 O-Glycosylation GlyGen 33214551, 28510447, 32870666, ...30397120, 34725712, 26853435, 30444036, 29351928, 34019948, 35083852, 31492838, 32119511, 35254053, 33465208
R585 Methylation PhosphoSitePlus
R587 Methylation PhosphoSitePlus
S588 O-Glycosylation GlyGen 33214551, 28510447, 32870666, ...30397120, 34725712, 26853435, 30444036, 29351928, 34019948, 35083852, 31492838, 32119511, 35254053, 33465208
S590 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
R592 Methylation PhosphoSitePlus   UniProt 24129315
S594 Phosphorylation PhosphoSitePlus   UniProt 22267324, 23186163
S594 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
R600 Methylation PhosphoSitePlus
Y602 Phosphorylation PhosphoSitePlus
R603 Methylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus   UniProt 23186163
S606 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S611 O-Glycosylation GlyGen 30444036, 28510447, 32870666, ...30397120, 34725712, 26853435, 33214551, 29351928, 34019948, 35083852, 31492838, 31373491, 32119511, 35254053, 33465208
S611 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S612 Phosphorylation PhosphoSitePlus   UniProt 18669648
S614 Phosphorylation PhosphoSitePlus
S615 O-Glycosylation GlyGen 31373491
S615 Phosphorylation PhosphoSitePlus
S616 O-Glycosylation GlyGen 33214551, 28510447, 32870666, ...30397120, 34725712, 26853435, 30444036, 30059200, 34019948, 35083852, 31492838, 35254053, 32119511, 29351928, 33465208
S616 Phosphorylation PhosphoSitePlus
R617 Methylation PhosphoSitePlus   UniProt 24129315
S619 Phosphorylation PhosphoSitePlus
R622 Methylation PhosphoSitePlus
R632 Methylation PhosphoSitePlus   UniProt 24129315
Y639 Phosphorylation PhosphoSitePlus
Y652 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 20068231
S57 Phosphorylation HPRD 20068231
S58 Phosphorylation HPRD 20068231
S61 Phosphorylation HPRD 18669648, 20068231
S62 Phosphorylation HPRD 20068231
S63 Phosphorylation HPRD 20068231
Y69 Phosphorylation HPRD 19901323, 16094384
S74 Phosphorylation HPRD 14729942, 17287340
S76 Phosphorylation HPRD 17287340
S78 Phosphorylation HPRD 17287340
S82 Phosphorylation HPRD 18669648, 18212344
S83 Phosphorylation HPRD 18212344
S92 Phosphorylation HPRD 18669648
S102 Phosphorylation HPRD 18212344
Y104 Phosphorylation HPRD 15592455
S125 Phosphorylation HPRD 17287340
T204 Phosphorylation HPRD 20068231
T323 Phosphorylation HPRD 20068231
Y343 Phosphorylation HPRD 17924679
S590 Phosphorylation HPRD 17924679
S594 Phosphorylation HPRD 19413330, 18212344, 19691289, ...19664995, 18669648, 19415658, 20068231, 17924679
S612 Phosphorylation HPRD 18669648