iPTMnet Report for O00519 (FAAH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00519 / FAAH1_HUMAN
Protein Name Fatty-acid amide hydrolase 1
Gene Name Name: FAAH
Synonyms:FAAH1;
Organism Homo sapiens (Human)

PRO ID PR:O00519
DAG View
PRO Name fatty-acid amide hydrolase 1 (human)
Definition A fatty-acid amide hydrolase 1 that is encoded in the genome of human.
Short Label hFAAH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00519 (FAAH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S88 Phosphorylation PhosphoSitePlus
T99 Phosphorylation HPRD   PhosphoSitePlus 20058876
S241 Phosphorylation PhosphoSitePlus   UniProt 24275569
S289 Phosphorylation PhosphoSitePlus
Y329 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
Y335 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K423 Ubiquitination PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T99 S99 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S430 L430 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S434 N434 Biomuta DOID:4159 / skin cancer [ cosmic ]
S440 L440 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]