iPTMnet Report for O00512 (BCL9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00512 / BCL9_HUMAN
Protein Name B-cell CLL/lymphoma 9 protein
Gene Name Name: BCL9
Organism Homo sapiens (Human)

PRO ID PR:O00512
DAG View
PRO Name B-cell CLL/lymphoma 9 protein (human)
Definition A B-cell CLL/lymphoma 9 protein that is encoded in the genome of human.
Short Label hBCL9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00512 (BCL9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S66 Phosphorylation HPRD   PhosphoSitePlus 18491316
S68 Phosphorylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S104 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19664994
S107 Phosphorylation PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
T155 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S157 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T161 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
T172 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S181 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S288 Phosphorylation HPRD   PhosphoSitePlus 19413330
S291 Phosphorylation HPRD   PhosphoSitePlus 20068231
S295 Phosphorylation PhosphoSitePlus
T308 Phosphorylation HPRD   PhosphoSitePlus 19413330
T315 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 15302935, ...19664994, 19664995, 18669648, 24275569, 19690332
S318 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...30620550, 35254053
S318 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17525332
S337 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...30620550, 35254053
S352 Phosphorylation HPRD   PhosphoSitePlus 18077418
S362 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
R620 Methylation PhosphoSitePlus
S687 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 15302935, ...19664994, 19664995, 17322306, 18669648, 19415658, 20068231
S689 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 23186163, ...19415658
S714 Phosphorylation PhosphoSitePlus
K844 Acetylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus
T888 Phosphorylation PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus   UniProt 21406692
S913 Phosphorylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S923 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus
T1031 Phosphorylation PhosphoSitePlus
S1034 Phosphorylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus
S1039 Phosphorylation PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus
K1244 Acetylation PhosphoSitePlus
R1254 Methylation PhosphoSitePlus
S1415 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35222 (CTNNB1) Y142 O00512 (BCL9) unknown eFIP 17052462


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 C11 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T32 S32 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S35 F35 Biomuta DOID:4159 / skin cancer [ cosmic ]
S47 C47 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S62 F62 Biomuta DOID:4159 / skin cancer [ cosmic ]
S82 R82 Biomuta DOID:1324 / lung cancer [ cosmic ]
K98 E98 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S107 P107 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S120 Y120 Biomuta DOID:4159 / skin cancer [ cosmic ]
S120 F120 Biomuta DOID:4159 / skin cancer [ cosmic ]
S120 C120 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S133 T133 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S136 F136 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T162 A162 Biomuta DOID:1324 / lung cancer [ cosmic ]
T164 P164 Biomuta DOID:1324 / lung cancer [ cosmic ]
S181 F181 Biomuta [ cosmic ]
S288 F288 Biomuta [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S352 C352 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S362 F362 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S362 P362 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
R620 C620 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S689 F689 Biomuta DOID:4159 / skin cancer [ cosmic ]
S857 P857 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S935 F935 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1039 C1039 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R1254 * Biomuta DOID:1612 / breast cancer [ cosmic ]