Protein Information

Cytoscape View

UniProt AC / UniProt ID O00505 / IMA4_HUMAN
Protein Name Importin subunit alpha-4
Gene Name Name: KPNA3
Organism Homo sapiens (Human)

PRO ID PR:O00505
DAG View
PRO Name importin subunit alpha-4 (human)
Definition An importin subunit alpha-4 that is encoded in the genome of human.
Short Label hKPNA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O00505 (KPNA3) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S6 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
T24 Phosphorylation HPRD   PhosphoSitePlus 18212344
S56 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19651622, ...18669648, 24275569, 19690332, 20068231
S60 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...23186163, 17081983, 20058876, 19664994, 19664995, 18452278, 19651622, 17322306, 18669648, 19690332, 24275569, 18318008, 19415658, 20068231
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
R103 Methylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus   UniProt 24275569
S486 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T24 K24 Biomuta DOID:3571 / liver cancer [ icgc ]
R103 S103 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S113 Y113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y474 C474 Biomuta DOID:0070003 / blastoma [ cosmic ]