iPTMnet Report for O00499 (BIN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00499 / BIN1_HUMAN
Protein Name Myc box-dependent-interacting protein 1
Gene Name Name: BIN1
Synonyms:AMPHL;
Organism Homo sapiens (Human)

PRO ID PR:O00499
DAG View
PRO Name Myc box-dependent-interacting protein 1 (human)
Definition A Myc box-dependent-interacting protein 1 that is encoded in the genome of human.
Short Label hBIN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00499 (BIN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K28 Acetylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
R66 Methylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K189 Acetylation PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
S296 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 24275569, 20068231
S298 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 24275569
S303 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163, ...17081983
T307 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19367720, 18669648, 17081983
T323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T327 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S331 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S333 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T348 O-Glycosylation GlyGen 35008409, 28510447, 29351928
T348 Phosphorylation PhosphoSitePlus
S350 O-Glycosylation GlyGen 35008409, 28510447, 29351928
S488 Phosphorylation phospho.ELM 18669648
S489 Phosphorylation phospho.ELM 18669648
T534 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
S296 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S298 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S303 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T307 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T323 Phosphorylation HPRD 18669648, 20068231
T327 Phosphorylation HPRD 18669648, 20068231
S331 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
S333 Phosphorylation HPRD 18669648, 20068231
T348 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K173 Acetylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
K173 Acetylation PhosphoSitePlus
S280 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20058876, 15302935, ...19651622, 19664994, 18669648, 18767875, 18510355, 20166139, 20068231
S282 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S287 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T291 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T307 Phosphorylation HPRD 18669648, 20068231
T311 Phosphorylation HPRD 18669648, 20068231
S315 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
S317 Phosphorylation HPRD 18669648, 20068231
T332 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
K173 Acetylation PhosphoSitePlus
S265 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S267 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S272 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T276 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T292 Phosphorylation HPRD 18669648, 20068231
T296 Phosphorylation HPRD 18669648, 20068231
S300 Phosphorylation HPRD   PhosphoSitePlus 20166139, 18669648, 17081983, ...20068231
S302 Phosphorylation HPRD 18669648, 20068231
T317 Phosphorylation HPRD 20068231
T334 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
S296 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S298 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S303 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T307 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T323 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
S265 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S267 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S272 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T276 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T292 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
S296 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S298 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S303 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T307 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T323 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
S265 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S267 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S272 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T276 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T292 Phosphorylation HPRD 18669648, 20068231
T296 Phosphorylation HPRD 18669648, 20068231
S300 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
S302 Phosphorylation HPRD 18669648, 20068231
T317 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
K173 Acetylation PhosphoSitePlus
S265 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S267 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S272 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T276 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T292 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
S280 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S282 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S287 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T291 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T307 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 20068231
S265 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19651622, 19664994, 18669648, 18510355, 20166139, 20068231
S267 Phosphorylation HPRD 19413330, 17322306, 20058876, ...19664994, 18452278, 19651622, 18510355, 18669648, 20166139, 20068231, 17924679
S272 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231
T276 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
T292 Phosphorylation HPRD 20068231
S304 Phosphorylation HPRD 18669648
S305 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K53 Q53 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic, cosmic, icgc ]
T56 M56 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K146 Q146 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y157 F157 Biomuta DOID:4159 / skin cancer [ cosmic ]
K173 N173 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S272 C272 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S276 N276 Biomuta DOID:1319 / brain cancer [ icgc ]
K282 E282 Biomuta DOID:1324 / lung cancer [ cosmic ]
S287 C287 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S303 C303 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S305 Y305 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
T334 S334 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, cosmic, cosmic, cosmic, cosmic, cosmic, cosmic, icgc, cosmic, cosmic ]
S489 Y489 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]