iPTMnet Report for O00472 (ELL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00472 / ELL2_HUMAN
Protein Name RNA polymerase II elongation factor ELL2
Gene Name Name: ELL2
Organism Homo sapiens (Human)

PRO ID PR:O00472
DAG View
PRO Name RNA polymerase II elongation factor ELL2 (human)
Definition An RNA polymerase II elongation factor ELL2 that is encoded in the genome of human.
Short Label hELL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00472 (ELL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T37 Phosphorylation PhosphoSitePlus
C99 Methylation IEDB 31844290
S145 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K470 Acetylation PhosphoSitePlus
K476 Acetylation PhosphoSitePlus
K486 Sumoylation PhosphoSitePlus
N500 N-Glycosylation GlyGen 29741879
S502 Phosphorylation phospho.ELM 18669648
S503 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S506 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T515 Phosphorylation PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus   UniProt 18691976
K584 Ubiquitination PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S305 Phosphorylation HPRD 20068231
S310 Phosphorylation HPRD 18452278
S315 Phosphorylation HPRD 18691976
S316 Phosphorylation HPRD 20068231
S502 Phosphorylation HPRD 18669648, 20068231
S503 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S506 Phosphorylation HPRD 18669648
S580 Phosphorylation HPRD 18691976, 20068231
S604 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S145 F145 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y258 S258 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S282 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K428 N428 Biomuta DOID:4159 / skin cancer [ cosmic ]
S502 A502 Biomuta DOID:263 / kidney cancer [ cosmic ]
S506 F506 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S580 F580 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S580 Y580 Biomuta DOID:2531 / hematologic cancer [ cosmic ]