Protein Information

Cytoscape View


UniProt AC / UniProt ID O00469 / PLOD2_HUMAN
Protein Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor
Gene Name Name: PLOD2
Organism Homo sapiens (Human)

PRO ID PR:O00469
DAG View
PRO Name procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (human)
Definition A procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 that is encoded in the genome of human.
Short Label hPLOD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00469 (PLOD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N63 N-Glycosylation GlyGen 29741879, 23345538
R76 Methylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
N209 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
K241 Ubiquitination PhosphoSitePlus
T320 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087
Y323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087
K329 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
Y387 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
Y444 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
N522 N-Glycosylation GlyGen   UniProt 19159218
K543 Ubiquitination PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
T634 Phosphorylation PhosphoSitePlus
Y655 Phosphorylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
N696 N-Glycosylation GlyGen 29741879
K704 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T320 Phosphorylation HPRD 18088087
Y323 Phosphorylation HPRD 18088087
Y437 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T320 Phosphorylation HPRD 18088087
Y323 Phosphorylation HPRD 18088087
Y437 Phosphorylation HPRD 20068231
K506 Ubiquitination PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K148 T148 Biomuta DOID:363 / uterine cancer [ tcga ]
K153 T153 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y163 F163 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
N209 I209 Biomuta DOID:9256 / colorectal cancer [ tcga ]
N209 K209 Biomuta DOID:3571 / liver cancer [ icgc ]
K241 N241 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K335 E335 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K335 I335 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K344 N344 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K355 E355 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S600 Y600 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y655 * Biomuta DOID:3571 / liver cancer [ icgc ]