Protein Information

Cytoscape View


UniProt AC / UniProt ID O00463 / TRAF5_HUMAN
Protein Name TNF receptor-associated factor 5
Gene Name Name: TRAF5
Synonyms:RNF84;
Organism Homo sapiens (Human)

PRO ID PR:O00463
DAG View
PRO Name TNF receptor-associated factor 5 (human)
Definition A TNF receptor-associated factor 5 that is encoded in the genome of human.
Short Label hTRAF5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00463 (TRAF5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
C161 S-Nitrosylation dbSNO 24105792
K225 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 R8 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K95 T95 Biomuta DOID:1324 / lung cancer [ tcga ]
C161 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K256 N256 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ icgc ]
K405 N405 Biomuta DOID:3571 / liver cancer [ icgc ]
K493 N493 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K539 E539 Biomuta DOID:1612 / breast cancer [ tcga ]