iPTMnet Report for O00459 (PIK3R2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00459 / P85B_HUMAN
Protein Name Phosphatidylinositol 3-kinase regulatory subunit beta
Gene Name Name: PIK3R2
Organism Homo sapiens (Human)

PRO ID PR:O00459
DAG View
PRO Name phosphatidylinositol 3-kinase regulatory subunit beta (human)
Definition A phosphatidylinositol 3-kinase regulatory subunit beta that is encoded in the genome of human.
Short Label hPIK3R2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00459 (PIK3R2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S34 Phosphorylation PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S262 Phosphorylation HPRD   phospho.ELM 18691976, 18669648
S263 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K343 Ubiquitination PhosphoSitePlus
Y365 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K371 Acetylation PhosphoSitePlus
K376 Acetylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
Y423 Phosphorylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation HPRD   PhosphoSitePlus 16497976
Y464 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17016520, 23186163, 18083107, ...15951569, 20068231, 16497976
Y467 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 16497976
T468 Phosphorylation HPRD   PhosphoSitePlus 20068231
K477 Ubiquitination PhosphoSitePlus
T487 Phosphorylation HPRD   PhosphoSitePlus 20068231
K541 Sumoylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
K564 Acetylation PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus
K598 Sumoylation PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
Y605 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17016520, 17389395, 19690332
K626 Ubiquitination PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
T643 Phosphorylation PhosphoSitePlus
Y655 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23604317
Y671 Phosphorylation PhosphoSitePlus
Y686 Phosphorylation HPRD 18083107
S688 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048771 (hPIK3R2/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00459 (PIK3R2) Y655 Q9UKC9 (FBXL2) inhibited_association eFIP 23604317
Phosphorylation P35568 (IRS1) S312 O00459 (PIK3R2) unknown eFIP 16505239


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 G34 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K343 R343 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K376 E376 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K376 M376 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S457 N457 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y467 H467 Biomuta DOID:1319 / brain cancer [ icgc ]
S562 N562 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K564 M564 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K564 E564 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
Y655 C655 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y671 H671 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]