iPTMnet Report for O00444 (PLK4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00444 / PLK4_HUMAN
Protein Name Serine/threonine-protein kinase PLK4
Gene Name Name: PLK4
Synonyms:SAK,STK18;
Organism Homo sapiens (Human)

PRO ID PR:O00444
DAG View
PRO Name serine/threonine-protein kinase PLK4 (human)
Definition A serine/threonine-protein kinase PLK4 that is encoded in the genome of human.
Short Label hPLK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00444 (PLK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S22 Phosphorylation O00444 (PLK4) neXtProt   PhosphoSitePlus 21985771
K45 Acetylation PhosphoSitePlus   UniProt 27796307
K46 Acetylation PhosphoSitePlus   UniProt 27796307
K50 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
T170 Phosphorylation O00444 (PLK4) neXtProt   PhosphoSitePlus   RLIMS-P 21985771, 26101219, 31142743
T174 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation O00444 (PLK4) neXtProt   PhosphoSitePlus 21985771
S255 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S282 Phosphorylation O00444 (PLK4) neXtProt 20100909
S285 Phosphorylation O00444 (PLK4) neXtProt 20100909
T289 Phosphorylation O00444 (PLK4) neXtProt 20100909
S291 Phosphorylation O00444 (PLK4) neXtProt 20100909
T292 Phosphorylation O00444 (PLK4) neXtProt 20100909
T295 Phosphorylation O00444 (PLK4) neXtProt 20100909
S297 Phosphorylation O00444 (PLK4) neXtProt 20100909
S298 Phosphorylation O00444 (PLK4) neXtProt 20100909
T300 Phosphorylation O00444 (PLK4) neXtProt 20100909
S301 Phosphorylation O00444 (PLK4) neXtProt 20100909
S303 Phosphorylation O00444 (PLK4) neXtProt 20100909
S305 Phosphorylation O00444 (PLK4) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 31142743, 20100909, 31000710, ...25174401, 20032307, 29712910
K321 Ubiquitination PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
R357 Methylation PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S406 Phosphorylation PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
S421 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K434 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
Y495 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K538 Acetylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
T591 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32501498, 23186163
S671 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
T751 Phosphorylation PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus   UniProt 19369195
S821 Phosphorylation PhosphoSitePlus   RLIMS-P 32501498
Site PTM Type PTM Enzyme Score Source PMID
S401 Phosphorylation HPRD 18691976
S421 Phosphorylation HPRD 18691976, 18669648
S499 Phosphorylation HPRD 18691976
S592 Phosphorylation HPRD 18691976
S671 Phosphorylation HPRD 18691976
S817 Phosphorylation HPRD 18691976


O00444 (PLK4) as PTM Enzyme



Substrate Site Score Source PMID
O00444 (PLK4) S22 neXtProt   PhosphoSitePlus 21985771
O00444 (PLK4) T170 neXtProt   PhosphoSitePlus 21985771
O00444 (PLK4) Y177 neXtProt   PhosphoSitePlus 21985771
O00444 (PLK4) S282 neXtProt 20100909
O00444 (PLK4) S285 neXtProt 20100909
O00444 (PLK4) T289 neXtProt 20100909
O00444 (PLK4) S291 neXtProt 20100909
O00444 (PLK4) T292 neXtProt 20100909
O00444 (PLK4) T295 neXtProt 20100909
O00444 (PLK4) S297 neXtProt 20100909
O00444 (PLK4) S298 neXtProt 20100909
O00444 (PLK4) T300 neXtProt 20100909
O00444 (PLK4) S301 neXtProt 20100909
O00444 (PLK4) S303 neXtProt 20100909
O00444 (PLK4) S305 neXtProt   PhosphoSitePlus   Signor 20100909, 20032307
O96004 (HAND1) T107 neXtProt 17891141
O96004 (HAND1) S109 neXtProt 17891141
Q15154 (PCM1) S372 PhosphoSitePlus 26755742
Q969U6 (FBXW5) S151 PhosphoSitePlus 21725316
Q96RT7 (TUBGCP6) S392 neXtProt 22302995
Q96RT7 (TUBGCP6) S1041 neXtProt 22302995
Q96RT7 (TUBGCP6) S1060 neXtProt 22302995
Q96RT7 (TUBGCP6) S1068 neXtProt 22302995
Q96RT7 (TUBGCP6) S1087 neXtProt 22302995
Q96RT7 (TUBGCP6) S1095 neXtProt 22302995
Q96RT7 (TUBGCP6) S1114 neXtProt 22302995
Q96RT7 (TUBGCP6) S1122 neXtProt 22302995
Q96RT7 (TUBGCP6) S1141 neXtProt 22302995
Q96RT7 (TUBGCP6) S1149 neXtProt 22302995
Q96RT7 (TUBGCP6) S1168 neXtProt 22302995
Q96RT7 (TUBGCP6) S1176 neXtProt 22302995
Q96RT7 (TUBGCP6) S1195 neXtProt 22302995
Q96RT7 (TUBGCP6) S1203 neXtProt 22302995
Q96RT7 (TUBGCP6) S1222 neXtProt 22302995
Q96RT7 (TUBGCP6) S1230 neXtProt 22302995
Q96RT7 (TUBGCP6) S1249 neXtProt 22302995
Q96RT7 (TUBGCP6) S1257 neXtProt 22302995
Q96RT7 (TUBGCP6) S1437 neXtProt 22302995
Q96RT7 (TUBGCP6) S1465 neXtProt 22302995
Q9HC77 (CENPJ) S595 neXtProt   PhosphoSitePlus   Signor 20531387


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 N8 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K45 N45 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K151 N151 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T174 N174 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S255 I255 Biomuta DOID:363 / uterine cancer [ icgc ]
S258 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S301 G301 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S303 I303 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K321 Q321 Biomuta [ cosmic ]
S330 N330 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S821 F821 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]