iPTMnet Report for O00443 (PIK3C2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00443 / P3C2A_HUMAN
Protein Name Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Gene Name Name: PIK3C2A
Organism Homo sapiens (Human)

PRO ID PR:O00443
DAG View
PRO Name phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (human)
Definition A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha that is encoded in the genome of human.
Short Label hPIK3C2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00443 (PIK3C2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S5 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
S60 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y68 Phosphorylation PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S108 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
K112 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
R139 Methylation PhosphoSitePlus
R175 Methylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S259 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 23186163, ...19369195, 12719431, 18669648, 24275569, 19690332, 20068231
S259 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12719431
K261 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K280 Methylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S329 Phosphorylation PhosphoSitePlus
T334 O-Glycosylation GlyGen 30379171, 31492838, 28657654, ...29351928
S336 Phosphorylation PhosphoSitePlus
S338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K348 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
Y406 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
K532 Acetylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
C541 S-Nitrosylation dbSNO 26338901
K542 Ubiquitination PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
K613 Methylation PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
T614 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus   UniProt 23186163
S665 Phosphorylation PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
Y737 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
S778 Phosphorylation PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
K872 Acetylation PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K881 Acetylation PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
K889 Acetylation PhosphoSitePlus
K889 Ubiquitination PhosphoSitePlus
K892 Ubiquitination PhosphoSitePlus
K898 Ubiquitination PhosphoSitePlus
Y900 Phosphorylation PhosphoSitePlus
Y901 Phosphorylation PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
K1062 Ubiquitination PhosphoSitePlus
S1084 Phosphorylation PhosphoSitePlus
K1088 Ubiquitination PhosphoSitePlus
K1096 Ubiquitination PhosphoSitePlus
K1158 Ubiquitination PhosphoSitePlus
K1162 Ubiquitination PhosphoSitePlus
K1209 Ubiquitination PhosphoSitePlus
K1217 Ubiquitination PhosphoSitePlus
S1281 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1327 O-Glycosylation GlyGen 30379171, 31492838, 28657654, ...29351928
S1335 O-Glycosylation GlyGen 30379171, 31492838, 28657654, ...29351928
S1412 Phosphorylation PhosphoSitePlus
K1414 Ubiquitination PhosphoSitePlus
T1415 O-Glycosylation GlyGen 30379171
S1417 O-Glycosylation GlyGen 30379171
S1551 Phosphorylation PhosphoSitePlus
S1553 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1595 Phosphorylation PhosphoSitePlus
K1597 Ubiquitination PhosphoSitePlus
K1606 Ubiquitination PhosphoSitePlus
K1611 Acetylation PhosphoSitePlus
Y1632 Phosphorylation PhosphoSitePlus
S1633 Phosphorylation PhosphoSitePlus
S1648 O-Glycosylation GlyGen 30379171, 31492838, 28657654, ...29351928
S1651 O-Glycosylation GlyGen 30379171, 31492838, 28657654, ...29351928
K1672 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S60 Phosphorylation HPRD 18669648
Y73 Phosphorylation HPRD 20068231
S108 Phosphorylation HPRD 18691976, 18669648, 20068231
S259 Phosphorylation HPRD 18691976, 18767875, 19664994, ...19007248, 19664995, 18669648, 20068231, 19691289
S338 Phosphorylation HPRD 18669648
S1551 Phosphorylation HPRD 19691289
S1553 Phosphorylation HPRD 18691976, 19691289


O00443 (PIK3C2A) as PTM Enzyme



Substrate Site Score Source PMID
P06730 (EIF4E) S209 RLIMS-P+ 7782349
P06730 (EIF4E) T210 RLIMS-P+ 7782349


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K11 E11 Biomuta DOID:1324 / lung cancer [ cosmic ]
K112 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K112 E112 Biomuta DOID:3571 / liver cancer [ cosmic ]
R175 I175 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S251 L251 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S259 F259 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K301 N301 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S327 C327 Biomuta DOID:4159 / skin cancer [ cosmic ]
S327 P327 Biomuta DOID:1612 / breast cancer [ cosmic ]
K532 Q532 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S673 I673 Biomuta DOID:1324 / lung cancer [ cosmic ]
S778 A778 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y901 H901 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1084 F1084 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1415 A1415 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1651 F1651 Biomuta DOID:4159 / skin cancer [ cosmic ]