iPTMnet Report for O00442 (RTCA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00442 / RTCA_HUMAN
Protein Name RNA 3'-terminal phosphate cyclase
Gene Name Name: RTCA
Synonyms:RPC,RPC1,RTC1,RTCD1;
Organism Homo sapiens (Human)

PRO ID PR:O00442
DAG View
PRO Name RNA 3'-terminal phosphate cyclase (human)
Definition An RNA 3'-terminal phosphate cyclase that is encoded in the genome of human.
Short Label hRTCA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00442 (RTCA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
C63 Methylation IEDB 31844290
K85 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K205 Methylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
C356 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
T184 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S49 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C356 R356 Biomuta DOID:4159 / skin cancer [ cosmic ]
C356 Y356 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C356 G356 Biomuta DOID:9256 / colorectal cancer [ cosmic ]