iPTMnet Report for O00429 (DNM1L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00429 / DNM1L_HUMAN
Protein Name Dynamin-1-like protein
Gene Name Name: DNM1L
Synonyms:DLP1,DRP1;
Organism Homo sapiens (Human)

PRO ID PR:O00429
DAG View
PRO Name dynamin-1-like protein (human)
Definition A dynamin-1-like protein that is encoded in the genome of human.
Short Label hDNM1L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00429 (DNM1L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895
S40 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 25192600
S44 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 25192600
T55 O-Glycosylation GlyGen 29351928, 34019948, 34725712, ...34764359, 28510447
T78 Phosphorylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
R108 Methylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
S200 O-Glycosylation GlyGen 29351928, 34019948, 34725712, ...34764359, 28510447
S200 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus   RLIMS-P 29022905
K271 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K283 Acetylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
C361 S-Nitrosylation dbSNO 26338901
C367 S-Nitrosylation dbSNO 19101475, 22178444
Y368 Phosphorylation PhosphoSitePlus   RLIMS-P 29022905
T394 Phosphorylation PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus   RLIMS-P 29022905
S529 Phosphorylation PhosphoSitePlus   UniProt 23186163
K532 Sumoylation PhosphoSitePlus
K535 Sumoylation PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S548 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S552 Phosphorylation PhosphoSitePlus
K558 Sumoylation PhosphoSitePlus
K568 Sumoylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
T586 Phosphorylation PhosphoSitePlus
K594 Methylation PhosphoSitePlus
K594 Sumoylation PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus   RLIMS-P 23813973
K597 Sumoylation PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K606 Sumoylation PhosphoSitePlus
S607 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K608 Sumoylation PhosphoSitePlus
S616 Phosphorylation P06493 (CDK1) , P28482 (MAPK1) , P27361 (MAPK3) , Q05655 (PRKCD) , Q00535 (CDK5) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21119009, 27831567, 32484300, ...32661251, 33723235, 35122996, 21406692, 21822277, 29654945, 32155766, 18234856, 25730670, 32433544, 24733894, 29620184, 29444369, 25012575, 22511751, 23792636, 29981473, 33302576, 27242436, 31363041, 31308800, 25658204, 25658205, 31746366, 32767829, 31551926, 22100972, 35952901, 30258050, 30471409, 29622847, 17301055, 29072687, 26057632, 30158524, 27837193, 18847512, 31324254, 18838687, 24177748, 35686673, 29262528, 33495511, 25993908, 32075676, 35670111, 25595902, 33236140, 23186163, 32346136, 26438559, 24275569, 31756635, 31387295, 19690332, 36078152, 33802063, 33087694, 24947026, 29463805, 29217195, 32232156, 33807275, 18669648, 27739424, 31019453, 35523103, 34475379, 23334860, 32863218, 33805672, 29520173, 18088087, 26122121, 35998797, 29531805, 31789589, 28981113, 20463395, 23283981, 26598294, 33924585, 20068231
S637 Phosphorylation P17612 (PRKACA) , Q13464 (ROCK1) , Q13131 (PRKAA1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 27242436, 27739424, 32848130, ...23979843, 29459657, 25595902, 33971394, 31019453, 32346136, 22745122, 18695047, 35952901, 25993908, 30444033, 30258050, 25730670, 32433544, 31533986, 26306039, 33805672, 29072687, 29520173, 26122121, 22326220, 33802063, 21701560, 27831567, 28981113, 30209302, 23792636, 33416159, 29217195, 18838687, 21478857, 26432782, 23283981, 23524851, 32398681, 33924585, 17553808, 27091447, 31994339, 32075676, 32351292
C644 S-Nitrosylation dbSNO 19417214, 22178444, 19342591
S693 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 23185298
T701 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T193 Phosphorylation HPRD 20068231
S194 Phosphorylation HPRD 20068231
S529 Phosphorylation HPRD 19664995
S548 Phosphorylation HPRD 18669648
S607 Phosphorylation HPRD 18669648
S616 Phosphorylation HPRD 19413330, 17322306, 18088087, ...18767875, 19664995, 19651622, 18669648, 20068231, 17924679
S684 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S544 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T193 Phosphorylation HPRD 20068231
S194 Phosphorylation HPRD 20068231
S526 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
S581 Phosphorylation HPRD 18669648
S590 Phosphorylation HPRD 19413330, 17322306, 18088087, ...18767875, 19664995, 19651622, 18669648, 20068231, 17924679
S611 Phosphorylation PhosphoSitePlus
S658 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T193 Phosphorylation HPRD 20068231
S194 Phosphorylation HPRD 20068231
K532 Ubiquitination PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus
S570 Phosphorylation HPRD 18669648
S579 Phosphorylation Q05655 (PRKCD) HPRD   neXtProt 19413330, 17322306, 18088087, ...18767875, 21119009, 19664995, 19651622, 18669648, 20068231, 17924679
S647 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00429 (DNM1L) S637 Q9NQG6 (MIEF1) unknown eFIP 21701560
Phosphorylation O00429 (DNM1L) S637 Q9GZY8 (MFF) unknown eFIP 26432782