Protein Information

Cytoscape View


UniProt AC / UniProt ID O00425 / IF2B3_HUMAN
Protein Name Insulin-like growth factor 2 mRNA-binding protein 3
Gene Name Name: IGF2BP3
Synonyms:IMP3,KOC1,VICKZ3;
Organism Homo sapiens (Human)

PRO ID PR:O00425
DAG View
PRO Name insulin-like growth factor 2 mRNA-binding protein 3 (human)
Definition An insulin-like growth factor 2 mRNA-binding protein 3 that is encoded in the genome of human.
Short Label hIGF2BP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00425 (IGF2BP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus   UniProt 21406692
S187 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
C257 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K258 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K465 Methylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K475 Sumoylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
K505 Acetylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
T528 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 23186163, ...19690332
K552 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S184 Phosphorylation HPRD 19651622, 20068231
S187 Phosphorylation HPRD 19651622
S243 Phosphorylation HPRD 20068231
T528 Phosphorylation HPRD 18669648
S571 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 W30 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K36 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K36 R36 Biomuta DOID:3070 / malignant glioma [ tcga ]
K280 N280 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K300 N300 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K300 * Biomuta DOID:1612 / breast cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic ]
K473 T473 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S496 C496 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K508 N508 Biomuta DOID:1909 / melanoma [ tcga ]
S576 T576 Biomuta DOID:1324 / lung cancer [ cosmic ]